#AlzheimersDisease

2025-11-05
I spent a few days earlier this year in rural Washington state and St. Louis, Missouri, for a New York Times story on Doug Whitney, a man who should have died two decades ago from early-onset Alzheimer's Disease, but somehow hasn't developed any symptoms. His mother was one of 10 siblings, out of 13, in her family who died from the disease; the family carries a genetic mutation that makes them more likely to develop early-onset Alzheimer's. Doug, now in his mid-70s, is the only known person in the world to have the mutation and not have symptoms of the disease, which usually present before one reaches mid-50s. Since discovering his genetic predisposition to the disease, he has been studied by researchers at Washington University in St. Louis, allowing doctors to poke, prod, scan, and do everything they need to figure out why he hasn't developed Alzheimer's. At his home, he sat with wife Ione and worked on jigsaw puzzles while I visited. In St. Louis, he underwent MRI and PET
scans, a spinal tap, blood draws, and other mental and physical examinations that he has been doing annually so the researchers can add to their long-term record of his genetics, physiological characteristics, and mental capabilities as he ages. One particular avenue of recent investigation is a significant build-up of heat-stress proteins in his brain possibly from his years working as a Navy mechanic, which some believe may make Doug less susceptible to the development of tau tangles in the brain, a hallmark of Alzheimer's disease. It was great to work so closely with Pulitzer-winning reporter Pam Belluck on this, whose health reporting I've sought out over the years.

A big thanks to Matt for the call on this assignment and for big play in the paper and online (with some video!)

#photography #photojournalism #news #health #science #onassignment #alzheimersdisease
2025-10-23

Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @PLOSBiology plos.io/49mmzcm

Neuroprotective (left) and neurotoxic (right) functions of disease-associated microglia (DAM). DAM are considered neuroprotective because they function as a physical barrier to limit plaque diffusion and because they phagocytically clear plaque-associated aggregates (β-amyloid or hTDP43 aggregates). Both mechanisms would lead to the protection of surrounding neurons from plaque-related neurotoxicity. A few studies have also pointed to a neurotoxic role for DAM. In these contexts, the presence of DAM causes increased T cell proliferation and pro-inflammatory signals in the brain, and DAM deactivation in the absence of Trem2–ApoE signaling reduces neuronal loss and axonal dystrophy. Figure created with BioRender.
Manchester Evening News: Number one for news, opinion, sport & celebrity newsmanchestereveningnews.co.uk@web.brid.gy
2025-10-19

Ten red flags of Alzheimer's disease that may be mistaken for exhaustion or stress

fed.brid.gy/r/https://www.manc

The Mirror: News, Sport, Celebrity & Entertainmentmirror.co.uk@web.brid.gy
2025-10-03

Scientist says 'answers may be hiding in plain sight' in predicting dementia risk

fed.brid.gy/r/https://www.mirr

Sharing the best of humanity with the world, one story at a time.upworthy.com@web.brid.gy
2025-10-02

Dutch 'dementia village,' a whole neighborhood designed for memory loss, is a game-changer

fed.brid.gy/r/https://www.upwo

Manchester Evening News: Number one for news, opinion, sport & celebrity newsmanchestereveningnews.co.uk@web.brid.gy
2025-09-23
Manchester Evening News: Number one for news, opinion, sport & celebrity newsmanchestereveningnews.co.uk@web.brid.gy
2025-09-22

NHS urges people to look out for four signs of early dementia as cases rise

fed.brid.gy/r/https://www.manc

IndieAuthors.Social Newsindieauthornews@indieauthors.social
2025-09-15

Free Fiction Monday: Elegy for Piano and Three Voices

When Alzheimer’s takes Stacey’s mother, Stacey gives up everything—her career, her music—to take care of her. Until one lonely night, when caretaking becomes too much, Stacy sits at the piano and plays Bach. She hopes to escape into the comfort…
kriswrites.com/2025/09/15/free

#freefiction #FreeFictionMondays #MondayFictionPost #AlzheimersDisease #caretakers
@indieauthors

2025-09-07

“It is unlikely that any #Jew, even one directly impacted by #antisemitism would be in favor of stopping research on, for example, #Alzheimersdisease, #heartdisease, or #autism to name a few, as a means of redressing their unrelated harm.” And she warned that, “if speech can be curtailed in the name of the #Jewish people today, then just as easily the speech of the Jews (and anyone else) can be curtailed when the political winds change direction.”

#antiintellectualism

newyorker.com/news/the-lede/ha

2025-09-06

Today is 4 years ago since I last heard my dad say my name.
Don't worry, imma just go cry in the corner for a bit 👌🏻🥲

#endalz #alzheimers #alzheimersdisease #alzheimersawareness

Biohacking Pathwaybiohackingpathway
2025-08-21

Is Dehydration Causing Alzheimer's?

Discover how dehydration contributes to Alzheimer's and dementia, impacting people in their 40s and 50s. Learn about crucial brain health factors and preventative measures in this insightful discussion. Protect your brain health today!

Follow @biohackingpathway for more

2025-08-20

'Women with Alzheimer’s have unusually low omega fatty acid levels, study finds'

"Analysis of blood samples finds women with the disease have 20% lower levels, a pattern not seen in men"

"There’s an indication that having less of these compounds could be causal in Alzheimer’s, but we need a clinical trial to confirm that."

"Several trials have found that giving older people omega-3 supplements did not improve their cognitive function or boost mental capacity in those already diagnosed with dementia."

"Legido-Quigley wants to see a clinical trial established to test whether supplements can delay Alzheimer’s disease specifically in women with low levels of unsaturated fatty acids, adding that the drop may start to appear when women are in their 50s. In the meantime, she said women should ensure they are getting omega fatty acids in their diets."

"There are three essential omega-3 fatty acids, known as ALA, DHA and EPA. ALA is found in plant-based foods such as chia seeds, flaxseed and walnuts. DHA and EPA primarily come from fish."

theguardian.com/science/2025/a

#health #Alzheimers #AlzheimersDisease #Omega3

David GraylessDavidGrayless
2025-08-15

in 2021, , German soccer striker (62 caps; FIFA World Cup 1974; Bayern Munich 453 games, 398 goals), died from at 75.
🕊️

David GraylessDavidGrayless
2025-08-15

in 2021, , German soccer striker (62 caps; FIFA World Cup 1974; Bayern Munich 453 games, 398 goals), died from at 75.
💐

Amelia Cervera 🧬ameliacervera@genomic.social
2025-08-13

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