#microglia

2025-11-05

MIT researchers invent new human brain model to enable disease research, drug discovery | MIT News

A new 3D human brain tissue platform developed by MIT researchers is the first to int…
#NewsBeep #News #Headlines #Alzheimer'sdisease #brainmodel #cerebrovasculature #dementia #extracellularmatrix(ECM) #Latvia #Li-HueiTsai #LV #microglia #MITKochInstitute #MITPicowerInstitute #MulticellularIntegratedBrains(miBrains) #neurons #personalizedmedicine #RobertLanger
newsbeep.com/231663/

2025-10-23

Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @PLOSBiology plos.io/49mmzcm

Neuroprotective (left) and neurotoxic (right) functions of disease-associated microglia (DAM). DAM are considered neuroprotective because they function as a physical barrier to limit plaque diffusion and because they phagocytically clear plaque-associated aggregates (β-amyloid or hTDP43 aggregates). Both mechanisms would lead to the protection of surrounding neurons from plaque-related neurotoxicity. A few studies have also pointed to a neurotoxic role for DAM. In these contexts, the presence of DAM causes increased T cell proliferation and pro-inflammatory signals in the brain, and DAM deactivation in the absence of Trem2–ApoE signaling reduces neuronal loss and axonal dystrophy. Figure created with BioRender.
2025-09-15

What's the role of microglial chromatin-mediated processes? This study shows that loss of ATRX in #microglia disrupts #chromatin structure, leading to de-repression of #retroelements & a viral mimicry #inflammation response that impairs hippocampal neuron function @PLOSBiology plos.io/46cBaE4

Top left: Immunofluorescence images of anti-GFP (green) and anti-ATRX (red) counterstained with DAPI (blue) illustrating absence of ATRX in Sun1GFP+ microglia nuclei in 2-month-old ATRX miKO mice. Scale bar, 50 µm.  Bottom left:  Representative images of microglia tracings; Sholl analysis reveals excessive branching in ATRX miKO compared to control microglia. Right: Immunofluorescence staining of CD68 (green) and Ai14+ (red) cortical and hippocampal CA1 microglia. Scale bar, 50 µm.

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