Unique Phenomenon of #H5 Highly Pathogenic Avian #Influenza Virus in #China: Co-circulation of Clade 2.3.4.4b #H5N1 and #H5N6 results in diversity of H5 Virus, https://etidiohnew.blogspot.com/2025/05/unique-phenomenon-of-h5-highly.html
#H5N6
Avian #influenza A(#H5N6) virus detected during live-poultry #market #surveillance linked to a #human #infection in #Changsha, #China, from 2020 to 2023, https://etidiohnew.blogspot.com/2025/04/avian-influenza-ah5n6-virus-detected.html
SciTech Chronicles. . . . . . . . . . . . . . . . . . . . .Jan 27, 2025
#DARPA #ground #aerial #swarms #OFFSET #tuberculosis #Kansas #active #latent #explosive #eruption #interaction #lava #water #poultry #flu #evolution #vaccines #H5N1 #H5N6 #Decommissioning #research #vessels #disadvantage #academic
Characterization of novel highly pathogenic avian #influenza A(#H5N6) clade 2.3.4.4b virus in wild #birds, East #China, 2024, https://etidiohnew.blogspot.com/2025/01/characterization-of-novel-highly.html
#Phylogenetic and #Pathogenic #Analysis of #H5N1 and #H5N6 High Pathogenicity Avian #Influenza Virus Isolated from #Poultry Farms (Layer and Broiler Chickens) in #Japan in the 2023/2024 Season, https://etidiohnew.blogspot.com/2024/12/phylogenetic-and-pathogenic-analysis-of.html
#Genetic #diversity of highly pathogenic avian #influenza #H5N6 and #H5N8 viruses in #poultry #markets in #Guangdong, #China, 2020-2022
Source: Journal of Virology, ABSTRACTH5 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/96 (Gs/Gd) lineage continue to evolve and cause outbreaks in domestic poultry and wild birds, with sporadic spillover infections in mammals. The global spread of clade 2.3.4.4b viruses via migratory birds since 2020 has…
#Epidemiological characterization of #human #infection with #H5N6 avian #influenza
Source: Frontiers in Public Health, Abstract Background: In recent years, there have been frequent reports of human infection with H5N6 avian influenza. However, the fundamental characteristics of the disease remain unclear. This paper conducts a systematic review to explore the epidemiological features of the disease, aiming to provide a foundation for epidemic prevention and control…
A #human #monoclonal #antibody targeting the monomeric #N6 #neuraminidase confers protection against avian #H5N6 #influenza virus infection
Source: Nature Communications, AbstractThe influenza neuraminidase (NA) is a potential target for the development of a next-generation influenza vaccine, but its antigenicity is not well understood. Here, we isolate an anti-N6 human monoclonal antibody, named 18_14D, from an H5N6 avian influenza virus (AIV) infected patient. The…
Farmed #fur #animals harbour #viruses with #zoonotic #spillover potential, Nature: https://www.nature.com/articles/s41586-024-07901-3
We identified 7 species of #coronaviruses, expanding their known host range, & documented cross-species transmission of a novel #canine respiratory coronavirus to raccoon dogs & of #bat HKU5-like CoV to #mink, present at a high abundance in lung tissues. 3 subtypes of #influenza A virus—#H1N2, #H5N6 & #H6N2—were detected in #lungs of guinea pig, mink and #muskrat, respectively.
#Influenza at #human - #animal interface - #Summary and #risk #assessment, from 8 June to 19 July 2024, #WHO: https://cdn.who.int/media/docs/default-source/influenza/human-animal-interface-risk-assessments/influenza-at-the-human-animal-interface-summary-and-assessment--from-8-june-to-19-july-2024.pdf?sfvrsn=3ebd42dc_3&download=true
New human cases: From 8 June to 19 July 2024, the detection of influenza A(#H5) virus in four humans, #H5N1 in 3 humans, #H5N6 in 1 human, and #H9N2 in 1 human were reported officially. Additionally, the detection of H1N2 variant #H1N2v virus in 2 humans was reported.
#HK CHP closely monitors a #fatal #human case of avian #influenza A(#H5N6) on #China Mainland, https://www.info.gov.hk/gia/general/202407/25/P2024072500502.htm?fontSize=1
The case involves a 70-year-old female living in #Hefei in #Anhui Province, who had visited a live #poultry #market before the onset of symptoms. She developed symptoms on June 17 and was admitted to a hospital for treatment on June 19. She passed away on July 8.
#China (People's Rep. of) -
#Influenza A #H5N6 viruses of high pathogenicity (Inf. with) (non-poultry including wild #birds) (2017-) - Immediate notification, #WOAH: https://wahis.woah.org/#/in-review/5717
Wild Species in Zhejiang.
#Influenza at the #human - #animal #interface, #summary and #assessment, 7 June 2024 - From 4 May to 7 June '24, release date 7 June '24, section: Emergency Situational Updates, #WHO: https://www.who.int/publications/m/item/influenza-at-the-human-animal-interface-summary-and-assessment--7-june-2024
From 4 May to 7 June '24, 4 human cases of infection with influenza #H5N1 viruses, 1 case of #H5N2 virus, 2 cases of #H5N6 viruses, & 3 cases of #H9N2 viruses were reported officially.
#China notified on 14/06/2024 to the #WHO of one additional #human #infection with #H5N6 avian #influenza virus in a #Fujian Province's male patient of 41 years old of age, Deceased, #HK CHP: https://www.chp.gov.hk/files/pdf/2024_avian_influenza_report_vol20_wk24.pdf
#COBRA #HA and #NA #vaccination elicits long-live protective immune responses against pre-pandemic #H2, #H5, and #H7 #influenza virus subtypes, Virology: https://www.sciencedirect.com/science/article/abs/pii/S0042682224001405?via%3Dihub
Multivalent vaccine was evaluated in both naïve & pre-immune mice to mimic immunity in humans. Both HA head- & stem-directed Abs levels were high in vaccinated mice. Little to no #lung #injury was observed in lungs of vaxed mice following challenge. Vaccine provided 4-mos-long protection vs clade 2.3.4.4 #H5N6 virus.
Fatal case of avian influenza A(H5N6) in Fujian, China (via UNMC). 👀
"52-year-old female living in Quanzhou city in Fujian Province, who had exposure to backyard poultry before the onset of symptoms. She developed symptoms on April 13 and was admitted to a hospital for treatment on April 20. She passed away on April 30."
#HK CHP closely monitors
#fatal #human case of infection with avian #influenza A(#H5N6) on #China, https://www.info.gov.hk/gia/general/202405/27/P2024052700500.htm?fontSize=1
A 52-year-old female living in #Quanzhou city in #Fujian Province, who had exposure to backyard #poultry before onset of symptoms. She developed symptoms on April 13 and was admitted to a hospital for treatment on April 20. She passed away on April 30.
Novel Avian #Influenza A(#H5N6) in Wild #Birds, South #Korea, 2023, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/6/24-0192_article
H5N6 viruses possessed molecular #markers T188, V210, Q222, & G224 in HA, are associated with binding affinity to α-2,3 SA receptors. S133A & T156A in HA, known to be associated with increased binding to α-2,6 SA receptors. L89V in PB2, but not Q591K, E627K, and D701N. D622G in PB1, N30D & I43M in M1, & P42S in NS1, associated with increased virulence in mice.
Concurrent #Infection with Clade 2.3.4.4b Highly Pathogenic Avian #Influenza #H5N6 and #H5N1 Viruses, South #Korea, 2023, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/6/24-0194_article
HPAI H5N6 & H5N1 viruses of clade 2.3.4.4b were simultaneously introduced into South Korea at end of 2023. An outbreak at a broiler duck farm consisted of concurrent infection by both viruses. Sharing genetic information and international surveillance of such viruses in wild birds and poultry is critical.
Identification of a novel #reassortant #H3N2 avian #influenza virus based on nanopore sequencing technology & genetic characterization, Zhonghua Liu Xing Bing Xue Za Zhi, https://pubmed.ncbi.nlm.nih.gov/38678355/
This study identified a novel reassortant H3N2 avian influenza virus by nanopore sequencing, with #PB1 gene derived from #H5N6 avian influenza virus. Virus had a low ability to spread across species, but further exploration was needed to determine whether its pathogenicity to the host was affected.
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