By @RTHM_Health

"A new study suggests that exercise doesn’t clear microclots in people with Long COVID—it just fragments them into smaller ones. These smaller clots are linked to increased inflammation and impaired oxygen transport, which may help explain post-exertional malaise (PEM) and post-exertional symptom exacerbation (PESE)—a worsening of symptoms after even mild physical or mental effort."

"Researchers observed these microclot and inflammatory changes even after submaximal exertion, highlighting the need for caution when recommending exercise-based therapies."

Want more research breakdowns like this? Sign up for our email list at https://linktr.ee/rthm_health

🔗 DOI: https://doi.org/10.21203/rs.3.rs-6717727/v1

#LongCOVID #ChronicFatigue #pwLC #PostCOVID #rthm_health #LongCOVIDResearch #PESE #PEM #IACC #COVID19 #Microclots @auscovid19

#SARSCoV2 persistence in platelet-producing lung cells:

"Accordingly, in all samples analyzed, circulating MK [megakaryocyte] in Long COVID sheltered both Spike and SARS-CoV-2 ssRNA [single-stranded RNA], but also dsRNA [double-stranded RNA] suggestive of viral replication. [...] Platelets microclots were detected in all tested Long COVID patients."

https://www.croiconference.org/abstract/persistence-of-sars-cov-2-in-platelets-and-megakaryocytes-in-long-covid/

#covid #covid19 #LongCovid #pandemic #MicroClots #PublicHealth #CovidIsNotOver

Long COVID still has no cure — so these patients are turning to research.

With key long COVID trials yet to yield results, people with the condition are trying to change how clinical trials are done.

By Rachel Fairbank

#LongCovid #MicroClots #nattokinase #serrapeptase #lumbrokinase #Putrino

https://www.nature.com/articles/d41586-024-00901-3

>>We conclude that the presence of fibrinaloid #microclots can indeed significantly account for the symptoms of #POTS associated with #LongCovid (and likely other syndromes), just as they can for other symptoms, post-exertional symptom exacerbation, and the generation of autoantibodies<<

Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10890060/

New research on severe #microclots and #POTS!

“We here develop the argument, with accompanying evidence, that fibrinaloid microclots, through their ability to block the flow of blood through microcapillaries and thus cause tissue hypoxia, are not simply correlated with but in fact, by preceding it, may be a chief intermediary cause of POTS, in which tachycardia is simply the body’s exaggerated ‘physiological’ response to hypoxia.”

https://www.mdpi.com/2075-4426/14/2/170

Many people with #LongCovid feel tired, unwell and in pain for lengthy periods after exercise, and researchers say they now know why. .

Experts say they have evidence that biological changes are to blame, such as severe #MuscleDamage, #mitochondrial problems and the presence of #microclots in the body.

Long Covid causes changes in body that make exercise debilitating – study | #Coronavirus | The Guardian
https://www.theguardian.com/world/2024/jan/04/people-with-long-covid-should-avoid-intense-exercise-say-researchers

We're learning more and more about long covid.

Plummeting levels of certain hormones may explain the fatigue and brain fog. "Microclots" in the blood may play a role. And the virus's ability to persist in our bodies may be crucial.

#LongCovid #microclots #ViralReservoir

https://www.newscientist.com/article/mg26034670-800-long-covid-what-we-now-know-about-its-causes-and-possible-treatments/
#science #scientist

We're learning more and more about long covid.

Plummeting levels of certain hormones may explain the fatigue and brain fog. "Microclots" in the blood may play a role. And the virus's ability to persist in our bodies may be crucial.

#LongCovid #microclots #ViralReservoir

https://www.newscientist.com/article/mg26034670-800-long-covid-what-we-now-know-about-its-causes-and-possible-treatments/

We're learning ever more about #LongCovid.

Plummeting levels of certain hormones may explain the fatigue and brain fog. "#microclots" in the blood may play a role. And the virus's ability to persist in our bodies may be crucial.

#ViralReservoir

https://www.newscientist.com/article/mg26034670-800-long-covid-what-we-now-know-about-its-causes-and-possible-treatments/
#science #scientist

We're learning ever more about #LongCovid.

Plummeting levels of certain hormones may explain the fatigue and brain fog. "#microclots" in the blood may play a role. And the virus's ability to persist in our bodies may be crucial.

#ViralReservoir

https://www.newscientist.com/article/mg26034670-800-long-covid-what-we-now-know-about-its-causes-and-possible-treatments/

Almost four years after the first cases of long covid emerged, we are accumulating evidence about the physiology behind this complex condition – from microclots to viral persistence

#LongCovid #microclots #ViralReservoir

https://www.newscientist.com/article/mg26034670-800-long-covid-what-we-now-know-about-its-causes-and-possible-treatments/

Almost four years after the first cases of long covid emerged, we are accumulating evidence about the physiology behind this complex condition – from microclots to viral persistence

#LongCovid #microclots #ViralReservoir

https://www.newscientist.com/article/mg26034670-800-long-covid-what-we-now-know-about-its-causes-and-possible-treatments/
#science #scientist

2/

People interested in this research might be interested in this talk, "Vascular pathology in post-viral conditions: the role of #Microclots" by Dr Nolan &
@resiapretorius from last December

https://www.youtube.com/watch?v=uDbwNFBz7Y8

#TeamClots #MEcfs #CFS #PwME #LongCovid #PwLC #postcovid @mecfs

MicroClots

How microclots and platelet pathology may be useful in clinical investigations:

Not only (simply) the size/numbers of micro clots present in healthy vs Long COVID but their:

- content
- activity
- biochemical characteristics

We cannot ignore the role of hyperactivated platelets in endothelialitis.

Ultimately, platelet pathologies and microclots are fundamentally involved in developing thrombotic endothelialitis.

https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0043-1774796

#Microclots #fluorogenicDyes

Fibrin microthrombi in bladder urothelium after #SARSCoV2 infection: Case report

https://shorturl.at/cmDN5

“this study suggest[s] increased levels of IL-8 in the bladder may drive microthrombi in the bladder vasculature & urinary IL-8 levels might provide a means of detecting if a patient is at risk for developing symptoms from these microthrombi after SARS-CoV-2 infection”

#TeamClots #MicroClots @longcovid
#LongCovid #PwLC #LC #PASC #postcovid
#COVIDー19 #COVID19 #COVID

2/

“Our findings highlight that label-free high-throughput microscopy can be used as a point-of-care technique to visualize and quantify the presence of microclots directly in plasma without the need for complicated sample preparation techniques.”

#microclots #TeamClots

Digital holo-tomographic 3D maps of #COVID19 #microclots in blood to assess disease severity

Free:
https://tinyurl.com/4kkrs76s

“fewer microclots and platelet aggregates were detected in the plasma of healthy controls when compared to #COVID-19 donors”

#teamclots @longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #postcovid @covid19
#COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2

1/

Children should not have to choose between health and education.

Cardiologist Rae Duncan

SEE ALSO
Cardiologist Rae Duncan "I want to talk about children"
https://youtu.be/hw0WNrRJl7A?si=dc8UxhVuO4JGseDD

#Children #Cardiologist #amiloyd #MicroClots #Schools

Larger current view on long covid
https://twitter.com/i/status/1701148986931884182

"NPR interviewed scientists who are looking at microclots found in the blood of people with #LongCOVID. These #microclots are unusual in that they are made up mostly of an abnormal type of fibrin and form unusual shapes called amyloid. These fibrin amyloid microclots may be a biomarker for long COVID. Another group had an article on microclots and long COVID. They suggest the term “spike protein induced thrombotic vasculitis” (SITV) to describe the pathophysiology of long #COVID #clotting."

https://drruth.substack.com/p/covid-news-and-more-52023

3/n