Lmst

Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:

🌍 https://www.fabriziomusacchio.com/blog/2025-06-29-astrocyte_enhance_plasticity/
📝 https://doi.org/10.1038/s42003-024-06540-8

#CompNeuro #Neuroscience

Fig. 4 from Squadrani et al. (2024)ꜛ: The model reproduces learning deficit in mutant mice. Top: State visit frequency over time. Bottom: Corresponding synaptic weight evolution for control and mutant simulations. Source: Communications Biology (Commun Biol)ꜛ (license: Creative Commons Attribution 4.0 International License)

📝 Open Access paper synthesising 10 principles within New Economics.

new economics is probably old economics?

https://www.nature.com/articles/s41893-025-01562-4

#Economics #Sustainability #Degrowth #Complexity #Interdisciplinary #OpenAccess #JournalClub #SocialEcologicalSystems

Four overlapping circles showing 10 principles of new economics grouped by ecological, social, political economy, and holistic. Holistic principles include social-ecological, interdisciplinary, and complexity thinking.

📝 🥁 Make some noise! Why agent-based modelers should embrace the power of randomness. https://rofasss.org/2025/05/31/noise/

#ABM #SocialComplexity #JournalClub

Postdocs at @iaacsic.bsky.social organised a #JournalClub to discuss recently published results. Discussion this week: the 'bio-signature' detection on K2-18b... going in strong with the controversy! :) #PlanetSci

Ahora que la gente de @ASAPbio está haciendo este llamado (en la captura) aprovecho para contar nuestra experiencia.

El año pasado convertimos parte de nuestro seminario del Departamento en el #IIBCE en un espacio de revisión de #peprints.
Entramos en un programa de ASAPbio y @prereview para los #journalclub y creamos #OSCU ( #openscience community #uruguay ). Es un espacio abierto e inclusivo para la revisión grupal de artículos fuera del circuito de las editoriales comerciales.
El impacto que tiene en la formación de la gente más joven es enorme, y el apoyo de PREreview es excelente.

Si te interesa, aquí está el link para más información https://prereview.org/clubs/open-science-community-uruguay

Si te dedicas a alguna #ciencia y todavía no conoces a los preprints, es hora de hacerlo. Si no te dedicas pero te interesa la ciencia, también.

#cienciaabierta #SurGlobal #eticadigital #accesoabierto @constanzasilvera

Captura de un toot de ASAPbio (@ASAPbio@mas.to) que dice (original en inglés):

Llamado a personas interesadas en:
Reforzar el potencial de los preprints and expandir su uso.
Rol de los preprints en mejorar la confianza e integridad.
Preprints en el Sur Global.
Reconocimiento institucional de los preprints.
Si esa persona eres tú, ¡haznos saber!

📝 🧀 Meltdown of trust in weakly governed economies.

“Neoliberal capitalism has created untrustworthy people and has (understandably) eroded not just trust in government but trust in private institutions and trust in each other. It has created a system that devours itself. None of this, however, is inevitable.”

paper arguing that it is essential to understand trust in well-functioning societies.

https://www.pnas.org/doi/10.1073/pnas.2320528122

#JournalClub #ComplexSystems #Trust

Very happy to have Heleen Wilbrink and Annelot Vijn from Utrecht Archives in our (online) Journal Club today taking about recent projects related to Records in Context (RiC-O) and Persons in Context ontologies as well as on transkribus-based HTR, LLM-based post processing and information extraction.

#archives @epoz @tabea @AnnaJacyszyn @heikef @enorouzi @joerg @sourisnumerique @GenAsefa #ontologies #semanticweb #lod #dh #culturalheritage #htr #transkribus #llms #journalclub

Screenshot of our Zoom-Session of the FIZ ISE Journal Club featuring Heleen Wilbrink and Annelot Vijn from Utrecht Archives.

#NeuroESC #JournalClub
Reading Mental exploration of future choices during immobility theta oscillations

If you've read it, will you let me know what you think?

The authors look at #ThetaSequences in a working memory task in a radial arm maze. They find theta during immobility (makes sense, e.g. we saw that in our two-goals task). They also find that theta sequences might preferentially represent the next goal (also makes sense, e.g. Hippocampal theta sequences reflect current goals)!

I have only done a quick reading so far, but am confused by a few points:

the decoding is done on all cells (pyramidals and interneurons), shouldn't it be done on pyramidal or #PlaceCells only?
the cell counts are quite low (often less than 40 pyrs) when I would have thought at least 50 place cells would be needed for this kind of maze. I guess that shows that #Neuropixels are not the best to record from dCA1!
the decoded algorithm itself includes a ' position transition matrix' which seems like it would bias decoding towards realistic trajectories that the rat is about to do??? (but I probably missed something)
also, this study is very related to this other paper, which is not discussed or even cited (😕 ):
Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze #CsisvariLab

Let me know what you think!

#LeutgebLab #NeuroRat #Neuroscience #SpatialCognition

#today lots of meeting admin for stuff next Wednesday (#JournalClub and inventors' club) , listening to a new #drumAndBass track on SoundClound that it touted to me over email (may be a first) and I have it on loop so it's good, and several short interesting meetings (eg for an extra #RepairCafe session with one uni, and a #Hackathon with another)...

MOAR COFFEE PLZ!

[Journal Club] Elucidation of the mechanism of [2Fe-2S] clusters biosynthesis
Iron-sulfur (Fe-S) clusters are ubiquitous metallocofactors constituting the active site of a multitude of enzymes and proteins involved in electron transfer, catalysis, sulfur donation and signalling. They are made of iron and sulfide ions assembled into diverse structures. The [
https://frenchbic.cnrs.fr/2025/02/04/elucidation-of-the-mechanism-of-2fe-2s-clusters-biosynthesis/
#JournalClub #Marseille #ParisSud

#today I am in at uni, have already hosted #JournalClub and shortly will be hosting departmental #teaTime, then hop on a train and at the same time see if anyone joins the PGR virtual social ... and then host the #inventorsClub ...

🎧 New Episode of #journalclub is out! Check out episode #269 of the podcast for more: https://buff.ly/4h1lqI0 #neotwitter #medtwitter #nicuverse #pedsICU #cardiology #nicu #innovation #podcast #babies #children

And the best opening line of the year goes to…

> Imagine that you’re trapped in the video game Minecraft and that the only way you can return to the real world is if you successfully approximate the values of various mathematical constants using the mechanics of the game.

https://arxiv.org/abs/2411.18464

#math #JournalClub

🎧 New Episode of #journalclub is out! Check out episode #260 of the podcast for more: https://buff.ly/41cAnCb #neotwitter #medtwitter #nicuverse #pedsICU #cardiology #nicu #innovation #podcast #babies #children

My latest #Neuroesc #JournalClub was on this:
Rat anterior cingulate neurons responsive to rule or strategy changes are modulated by the hippocampal theta rhythm and sharp-wave ripples

I won't do a super-long summary like last time, but please share your thoughts if you've read it!

The author line-up is quite interesting, I think they were all students at the time of data collection which seems to have happened a long time ago, and now many are PIs (@BenoitGirard probably knows about the backstory...)! Probably a pandemic paper??

The scientific question (what supports rule recognition and strategy shift) is really interesting, and they record in the frontal cortex (#ACC) as well as #Hippocampus (ventral CA1!), but the rats just were not up to the task (1/5 rats actually did what they wanted). I am also not fully convinced by some of the analysis. @jessetm I'd be interested to know what you think of their strategy detection method!

Why is it that all papers looking at these themes always end up being.. quite complex??

#Neuroscience #NavigationStrategies #theta #swr #NeuroRat

#JournalCLub

Client Info