Monocytes: normal values and causes of their increase/decrease in blood #monocytes #whitebloodcells
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#Monocytes
Monocytes: normal values and causes of their increase/decrease in blood #monocytes #whitebloodcells
... Continue to: https://youtube.com/shorts/eae1l3f2bGU?si=P1bJ3y9p4TMN9C25
Monocytes: normal values and causes of their increase/decrease in blood #monocytes #whitebloodcells
... Continue to: https://youtube.com/shorts/eae1l3f2bGU?si=P1bJ3y9p4TMN9C25
#Remyelination in the CNS is influenced by myeloid cells, including resident #microglia & infiltrating #monocytes. This study shows that infiltrating monocytes inhibit the efficiency of CNS remyelination @PLOSBiology https://plos.io/3RryCLF
Human aging is assoc. with inflammation and intestinal barrier dysfunction. One might assume that barrier permeability would spark increased inflammation. This (and prev.) work suggests the opposite—that #inflammaging, driven by #monocytes and #macrophages appear to *cause* the barrier dysfunction!
Question to anyone familar with #TransHealthcare #Hematology
Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?
#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.
Infiltrating #monocytes drive #cardiac #dysfunction in a #cardiomyocyte-restricted mouse model of #SARS-CoV-2 infection, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.01179-24?af=R
These findings establish a mouse #model of SARS-CoV-2 cardiomyocyte infection that recapitulates features of cardiac dysfunctions of COVID-19 and suggests that both viral replication and resultant innate immune responses contribute to cardiac pathology.
13/ 🔗 Read the full paper here: https://www.embopress.org/doi/full/10.1038/s44321-024-00093-3
#Immunology #Research #Platelets #Monocytes #Inflammation #EMBO #Science #MedicalResearch
" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"
https://insight.jci.org/articles/view/179433
Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.
Zombie Nerves Cause Lingering Bladder Infection Pain: New studies from Duke University. #uti #urinarytractinfection #recurrent #nerveovergrowth #mastcell #monocytes
https://www.instagram.com/p/C4gPLBTLnTz/
#Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived #monocytes for enhanced tumor growth
Tsuyoshi Osawa et al show that low-oxygen conditions induce lineage-specific activation of #SREBP2 via #Golgi-ER fusion, promoting lipid biosynthesis, myeloid cell infiltration, and #tumorigenesis
https://www.embopress.org/doi/full/10.15252/embj.2023114032
Very exciting that this paper is out now in #cancercell: https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00216-7
In brief: we show that in esophageal #adenocarcinoma #checkpoint #therapy success is predicted by an independent combination of mutation burden and the amount of #monocytes in the tumour pre-treatment (as measured by RNAseq). Very exciting link between #myeloid cells and #immune response to #cancer!
"NB cells signal to the BM microenvironment, rewiring via macrophage migration inhibitory factor and #midkine signaling specifically #monocytes ..."
#Neuroblastoma paper by Fetahu et al., the latest publication from the Taschner-Mandl lab in Vienna.
Going through this right now - very alike our own work - and talking to a few team members on Wednesday while they visit our center.
#macrophages #scATACseq #scRNAseq #OpenAccess #cancer #immunology
Data available on EGA, behind a DAC.
#Monocytes and the neurological health of #LongCovid Patients
https://boingboing.net/2023/05/10/monocytes-and-the-neurological-health-of-long-covid-patients.html
https://www.scientificamerican.com/article/long-covid-now-looks-like-a-neurological-disease-helping-doctors-to-focus-treatments/
@LangzeitC This article is a perfect example of why #covid media coverage is part of the problem.
Article:
197! differences in the #epigenetics of #monocytes from #LongCovid patients! Whoot? 😱😱😱
Reading the actual paper, which can be found here:
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-022-01398-1#MOESM1
you will find it is based on 10(!) patients and that there is an arbitrarily chosen difference of #methylation of 0.2 that leads to that number of 197. What that means? Who knows? But its enough to ventilate it..
#Innate and #Adaptive #Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms
#COVID19 #Bcells #neutrophils #dendritic_cells #Tcells #NKcells #monocytes #macrophages #SARSCoV2
https://www.mdpi.com/2076-393X/11/2/408
Second great thread from @jeffgilchrist explaining ways Covid gets around our immune system’s. Here he describes how it shifts monocytes from their protective function to one that leads to more clotting. And, the virus basically grows your nasal cilia like jack and the bean stock (his analogy) to bypass protective mucus.
Fascinating and gnarly.
The paper focuses on #DendriticCells (DC) and #monocytes from a local inflammatory site, in this case synovial fluid from swollen joints of mainly juvenile #arthritis patients.
Very short: one type of DC were very much enriched but seemed relatively quiescent despite the inflammatory surroundings, while other DC and monocytes behaved clearly pro-inflammatory.
Last week, the paper based on my work in the Wilhelmina Children's Hospital (WKZ) was published, with the title "Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis".
https://doi.org/10.3389/fimmu.2022.1101999
Credits to Anoushka Samat for taking care of this after I left the department. Without her this work would not be out there. And of course thanks to the rest of the team.
#immunology #RNAseq #inflammation #DendriticCells #monocytes
Great thread by Dr Gilchrist @jeffgilchrist
How COVID actively suppresses and evades your immune system
“ how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose”
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