#TranslationalResearch

2025-10-28

Finally, this work would not have been possible without the input and work from all my co-authors from UK, France, Italy and USA. I am grateful that I could be part of this journee and want to thank also the #FoundationForPraderWilliResearch (#FPWR) for their generous funding! I hope that this research may at some day contribute to improve the life of patients with #PraderWilliSyndrome (#PWS) or other #RareDiseases.

#TranslationalResearch #INFRAFRONTIER #IMPC

Lexmilian S. R. B. de MelloPercarus@mastodon.au
2025-09-25
2025-09-17

Tomorrow, September 18, 2025, we will announce the laureate(s) of the first-ever Broermann Medical Innovation Award.

Who will be recognized for research that is & will save lives?

Stay tuned.

Tomorrow, September 18, 2025, we will announce the laureate(s) of the first-ever Broermann Medical Innovation Award.

Who will be recognized for research that is & will save lives?

Stay tuned.


#BroermannAward #MedicalInnovation #ScienceRecognition #TranslationalResearch #FutureOfMedicine
CSBJcsbj
2025-08-17

🤖 Can algorithms outsmart evolution to create therapies humans never imagined?

🔗 Computational nanobody design through deep generative modeling and epitope landscape profiling. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2025.07

📚 CSBJ: csbj.org/

Computational nanobody design through deep generative modeling and epitope landscape profiling. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.052
2025-07-23

Job - Alert 🩺

Independent Junior Research Group Leader in “Translational Cancer Research“

Deadline: 2025-08-18
Location: Germany, Berlin

academiceurope.com/ads/indepen

#hiring #CancerResearch #TranslationalResearch #BiomedicalScience #medicine #lifescience #datascience

2025-06-18

📢 Save the date! Our next IRIS Insights is coming up this Thursday, June 26 at 2:00 PM (CEST).

We’re delighted to welcome Prof. Monilola Olayioye, who will speak on:
🎙️ "Tumors in Dishes: New Opportunities for Personalized Medicine"

In her talk, Prof. Olayioye will explore how patient-derived tissue samples can be used to advance cancer treatment. She’ll share insights from the 3R-US team on developing human tumor models – often called “tumors in dishes” – and how they are applied in the lab to test new therapies. The talk will also highlight approaches like bioprinting, alternatives to animal testing, and cancer biotherapeutics designed to activate the immune system.

🎯 The goal: more personalized and more effective cancer therapies.

This is the third talk in our IRIS Insights series, which showcases interdisciplinary research from the IRIS community and provides a space for dialogue across fields.

🗓️ Thursday, 26 June
🕑 2:00 PM (CEST)
🔗 Join via Webex – link in bio/comments
🗣️ Language: English

We’re looking forward to an inspiring session and hope to see you online!

#IRISInsights #CancerResearch #3R #PersonalizedMedicine #Bioprinting #TumorModels #ScienceCommunication #SRFIRIS #UnivStuttgart
#BiomedicalResearch #Immunotherapy #FutureOfMedicine #TranslationalResearch #HumanTissueModels #NoAnimalTesting #OpenScience
#LifeSciences #HealthInnovation #AcademicTalk #InterdisciplinaryResearch #MedicalInnovation #WomenInScience #ScienceEvent #UniversityResearch

IRIS Board of Directors
Prof. Dr. André Bächtiger
Prof. Dr. Reinhold Bauer
Prof. Dr. Sibylle Baumbach
Dr. Miriam K.
Prof. Dr. @ai Staab
Jun.-Prof. Dr. Maria Wirzberger

CSBJcsbj
2025-06-11

🧬 Are we overcomplicating proteomics—when a few unique sequences can tell the whole story?

🔗 Uniquome: Construction and decoding of a novel proteomic atlas that contains new peptide entities. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2025.05

📚 CSBJ: csbj.org/

Uniquome: Construction and decoding of a novel proteomic atlas that contains new peptide entities. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.027
2025-05-20

Today, on International Clinical Trials Day, we celebrate the perseverance, precision, and ethical responsibility that define this essential part of medical progress

Because without clinical trials, innovation remains a theory.

clinical trialsclinical trialsclinical trialsclinical trials
2025-05-10

How can we better understand DLBCL? This new neural network, DLBclass, tackles this by assigning almost all cases to their C1-C5 genetic subtypes, unlocking valuable genetic information. #translationalresearch #hematology #deeplearning ashpublications.org/blood/articl...

DLBclass: a probabilistic mole...

AP-HM - CHU de Marseilleaphm_chu_marseille
2025-04-18

Éric Vivier reçoit le prestigieux Prix international Fondation ARC Léopold Griffuel de recherche translationnelle et clinique 🏆🔬
👏 Une belle reconnaissance pour ses travaux sur l’immunité innée et le développement de nouvelles immunothérapies contre le cancer.
📎 linkedin.com/feed/update/urn:l

Portrait d’Éric Vivier en costume bleu, regard tourné vers l’objectif, en extérieur avec un arrière-plan flouté de verdure.Photo de la remise du Prix Fondation ARC Léopold Griffuel 2024 : Éric Vivier au centre brandit le trophée, entouré de deux personnalités, devant un écran coloré affichant son nom et sa photo.
DrBob, 🧠 Mechanicdrrjv@vmst.io
2025-03-30

Remember the movie Re-Animator? Well, it’s back 😳

en.m.wikipedia.org/wiki/Re-Ani

Yale researchers restored circulation and cellular function in pig brains four hours postmortem using a perfusion system (BrainEx), preserving synaptic activity and gene expression. This work redefines the limits of ischemic damage and raises critical neuroethical concerns about the definition of brain death.

apple.news/AL6zxgB09T-CV44DVvq
#Neuroscience #BrainEx #Neuroethics #ReAnimator #TranslationalResearch #BrainDeath #MedicalEthics #CNS

2024-07-10

A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis. doi.org/10.1038/s41467-024-470 #StemCellResearch #Hepatology #TranslationalResearch

article figure
Nicola Romanònicolaromano@qoto.org
2024-07-09

New #preprint on #biorxiv!

"Rodent chronic variable stress procedures: a disjunction between stress entity and impact on behaviour"

biorxiv.org/content/10.1101/20

We systematically investigated 350+ studies using chronic variable stress procedures in rodents and assessed the characteristics of the procedure (how many stressors they used, and how many different types, and for how long), then measured the reported effect size for those using behavioural tests as an outcome.

Some key disconcerting findings from our study

- the large majority of articles uses a unique protocol, and articles featuring the same protocol were from the same authors (aside from one case)
- 91% of articles don't provide any justification for their choice of procedure

This is scientifically and ethically troubling given CVS procedures deliberately impose suffering to animals.

- when looking at the outcome behavioural procedures measured in the studies (some of which impose further stress on the animals) we found very little correlation between effect size and the characteristics (eg length, strength) of the stress protocol. When there was a statistically significant effect, this was generally very small.

We conclude

"Most of the studies in our review sought evidence for interventions that would prevent or reverse the effects of chronic stress. But if we are to have any confidence that translational CVS studies provide a foundation for potential clinical interventions, we must take an evidence- and ethics-informed approach to their design."

#chronicVariableStress #stress #reproducibility #ethics #effectSize #translationalResearch #physiology

2023-08-20

The Autism Research Lab is looking for a postdoc and technician in Philly. We study the efficacy of peptides on neural circuits and behaviors using autism mouse models. Please email me at kt469@drexel.edu. toyooka-lab.academic.ws/
#autism #asd #translationalresearch #neuroscience #neurobiology #postdoc #researchassistant #jobs

2023-04-12

#Scientists Dr. Melissa Hudson and Dr. Jun J. Yang will be honored for their #clinical and #TranslationalResearch contributions at the #AACR23 meeting in #Orlando from April 14-19. Learn about their careers and the #science they and their #StJude peers will share. bit.ly/3MRwwnh #CancerResearch #StJudeResearch

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