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Tom Kindlontomkindlon@disabled.social
2025-06-20

"Our data show #SARSCoV2 N protein exacerbates pathological pain in mouse models of bone cancer, chemotherapy, neuropathic, & inflammatory, & promotes the chronification of acute inflammatory pain"

journals.lww.com/pain/fulltext

Image from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

PAIN SARS-CoV-2 N protein interacts with Nav1.7 to promote pathological pain — Liu, Jin-Kun et al. "Our data show that SARS-CoV-2 N protein exacerbates pathological pain in mouse models of bone cancer, chemotherapy, neuropathic, and inflammatory, and promotes the chronification of acute inflammatory pain. We also identify a potential interaction between the N protein and Nav1.7 in dorsal root ganglion neurons from mice, monkeys, and humans."
Tom Kindlontomkindlon@disabled.social
2025-06-20

"the proportion of children in the survey who reported good or very good health reduced from 82.6% before NZ's two large Omicron waves to 66.9% after these waves"

onlinelibrary.wiley.com/doi/10

Image from @s4me update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19
#LongCovidKids #LCKids

Journal of Paediatrics and Child Health Post-Covid-19 Symptoms in Children: A Cross-Sectional Survey — Julie Bennett et al. "the proportion of children in the survey who reported good or very good health reduced from 82.6% before NZ's two large Omicron waves to 66.9% after these waves, with changes in health significantly more frequent in those who had a Covid-19 infection compared with those who had not."
Tom Kindlontomkindlon@disabled.social
2025-06-18

"In this paper, it is hypothesized that reduced oxygen tension in skeletal muscle is indicative of COVID-19 disease severity and predictive of subsequent progression in severity of illness"

sciencedirect.com/science/arti

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

Medical Hypotheses Skeletal muscle oxygen tension as a measure of COVID-19 disease severity and predictor of disease progression — Stacey et al. "In this paper, it is hypothesized that reduced oxygen tension in skeletal muscle is indicative of COVID-19 disease severity and predictive of subsequent progression in severity of illness."
Tom Kindlontomkindlon@disabled.social
2025-06-18

From India:

Executive Function Decline and Its Association With TNF-α in the Later Stages of Post-Acute Sequelae of COVID

onlinelibrary.wiley.com/doi/ab

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Journal of Neuroscience Research Executive Function Decline and Its Association With TNF-α in the Later Stages of Post-Acute Sequelae of COVID — Aditi Varenya et al. "EF decline in PASC also showed a significant, moderate, inverse relationship with serum TNF- α levels. No such correlations were observed in the HC group. Furthermore, serum TNF- α levels were significantly predictive of the variance in EF decline, after controlling for the impact of age and education" "Notably, serum TNF- α concentrations were significantly higher in females, relative to males, in the PASC group."
Tom Kindlontomkindlon@disabled.social
2025-06-18

From Italy:

Post-COVID-19 exaggerated exertional tachycardia: Relationship with pulmonary and cardiac sequelae

heartandlung.org/article/S0147

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19 #auscovid19

Heart & Lung: The Journal of Cardiopulmonary and Acute Care Post-COVID-19 exaggerated exertional tachycardia: Relationship with pulmonary and cardiac sequelae — Giovanna Pelà et al. "We found a significant reduction in lung diffusion capacity and in mean oxygen saturation during the 6MWT in [Exaggerated Exertional Tachycardia] patients compared to [Normal Exertional Tachycardia] ones."
Tom Kindlontomkindlon@disabled.social
2025-06-18

Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes

pubs.acs.org/doi/full/10.1021/

Image is from the latest Science for ME weekly update

#LongCovidKids #MIS_C #LCKids @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Journal of Proteome Research Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes — Nathan G. Lawler et al. "We provide comprehensive metabolic profiles of children with acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C) resulting from acute COVID-19 infection, revealing both have significant metabolic perturbations similar to those seen in adults." "The persistence of inflammatory and cardiovascular markers postinfection raises concerns about long-term health impacts, underscoring the need for vigilant monitoring, potential interventions, and further studies to understand the lasting effects of SARS-CoV-2 infection on pediatric health."
Tom Kindlontomkindlon@disabled.social
2025-06-18

COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID

Image is from the latest Science for ME weekly update

biorxiv.org/content/10.1101/20

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19 #auscovid19

Preprint: BioRxiv COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID — Soneida DeLine-Caballero et al. "our results revealed no evidence of persistent viral RNA in [subcutaneous adipose tissue] samples from either subacute or LC cohorts." "Transcriptome analysis of SAT samples did not distinguish participants with significant LC symptoms from indeterminant subjects. These findings suggest that SAT remodeling does not play a major role in driving Long COVID sequelae."
Tom Kindlontomkindlon@disabled.social
2025-06-18

New US research

SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19

biorxiv.org/content/10.1101/20

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver @auscovid19 #auscovid19

Preprint: BioRxiv SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19 — Aiswarya Mukundan Nair and Helen Piontkivska "Our results suggest that SARSCoV-2 infection can lead to persistent changes in ADAR editing patterns even after viral clearance." "we propose persistent dysregulation in ADAR editing of host transcripts, including in genes involved in the neutrophil degranulation pathway, as one potential contributor to some of the symptoms observed in post-SARS-CoV-2 infection sequelae in a subset of individuals."
Sebastian Müllersbamueller@freiburg.social
2025-06-17

Unbedingt den super Artikel zur #PostCOVID lesen!

Das ganze Phänomen wird super zusammengefasst und die richtigen Fragen gestellt: etwa die Frage wie viele Leute hatten eigentlich #Corona, Haben es aber nicht bemerkt und glauben jetzt, dass die #PostVAC haben!

From: @laborjournal
mstdn.science/@laborjournal@ms

Deacon Jerichobetter_tomorrow@mastodon.online
2025-06-16

Seit September 2024 gab es nun den 5. Schlaganfall in meinem näheren Verwandten- und Bekanntenkreis. Rechnet man noch 1 Jahr drauf, ist es schon der 7. Ist aber bestimmt normal bzw. alles nur Zufall.

#Stroke #Schlaganfall #LongCovid #PostCovid #CovidIsNotOver

melmel@social.sdf.org
2025-06-16

purplepingers speaking truth to power

youtu.be/s5E5gnTtRSo

#returnToOffice #workFromHome #class #autonomy #exploitation #postCOVID #productivity

Fatigatio e.V.FatigatioeV
2025-06-16

News aus der Hamburg: Die CDU bringt am 18.06. einen Antrag mit dem Titel "Versorgung bei ME/CFS und Post-COVID in Hamburg ausbauen und verbessern" in die Hamburger Bürgerschaft ein.

Die RG HH ünterstützt die Kernforderungen:
✔ Kompetenzzentrum mit Ambulanz
✔ Aufklärung & Info-Kampagnen
✔ Pflicht-Fortbildungen
✔ Anerkennung als somatische Erkrankung
✔ Verankerung in Lehre & Forschung

Mehr Infos: fatigatio.de/aktuelles/detail/

Tom Kindlontomkindlon@disabled.social
2025-06-16

The Bethesda Declaration:
"Based on political preferences and without input from NIH scientific staff or Congress, NIH is censoring critical research and programs addressing: #COVID19, #longCOVID, and immunization"

standupforscience.net/bethesda

s4me.info/threads/impacts-of-t

Image from Science for ME update

#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver

Stand Up For Science The Bethesda Declaration: A Call for NIH and HHS Leadership to Deliver on Promises of Academic Freedom and Scientific Excellence A group of NIH employees have written an open letter addressed Dr. Bhattacharya, director of the National Institutes of Health. The letter includes this section: "Based on political preferences and without input from NIH scientific staff or Congress, NIH is censoring critical research and programs addressing: - COVID-19, long COVID, and immunization. We still have much to learn about the health and social consequences of COVID-19 and our response. Such research is needed to reduce the risk of future pandemics, optimize pandemic response policies, and address the well-documented and debilitating consequences of long COVID." The forum thread includes links to multiple news outlets that have covered this story. Bethesda Declaration | Thread
Tom Kindlontomkindlon@disabled.social
2025-06-15

Creatine and Post-Viral Fatigue Syndrome: Can a Gym Supplement Support Brain Recovery?

propstmetabolichealth.substack

Comment: I've been taking 12 g/day of Creatine for many months now (with a break every 6 weeks).
This may be contributing to me feeling better.

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

1/

Creatine and Post-Viral Fatigue Syndrome: Can a Gym Supplement Support Brain Recovery? David Propst Jun 07, 2025 A month ago, I shared a post exploring the potential of creatine in managing post-viral fatigue. Just yesterday, an updated peer-reviewed study was published and it adds important new insights. Published in the Journal of the International Society of Sports Nutrition, the paper dives deeper into creatine’s role in energy metabolism, cognitive recovery, and long COVID–related fatigue. Let’s break down what’s new, what it confirms, and what it means for anyone navigating post-viral fatigue.
Tom Kindlontomkindlon@disabled.social
2025-06-15

Seeing the Invisible: Illuminating brain function in ME/CFS & #LongCovid

youtu.be/3-54JAgZ2x8

Dr Chris Armstrong & his team at OMF’s Melbourne ME/ #CFS Collaboration are investigating the link between neuroinflammation, cerebral blood flow, & dysregulated hormones in #MECFS, #POTS, & Long #COVID

#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #PwME @pots #PwLC #PASC #postcovid @longcovid
#CovidBrain
#COVID19 #SARSCoV2 #CovidIsNotOver #auscovid19 @auscovid19

Tom Kindlontomkindlon@disabled.social
2025-06-15

"Minnesota’s Long COVID Funding Saved from Elimination"

The first-in-the-nation #LongCOVID program, run by the Minnesota Department of Health (MDH), has been saved from budget cuts. “Advocacy works,” said Terri Wilder, chair of #MEAction’s Minnesota chapter

thesicktimes.org/2025/06/11/mi

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2

Tom Kindlontomkindlon@disabled.social
2025-06-14

Some low-energy products for washing one's hair

From: May 2025 Caregiver Call Summary

Links:
walgreens.com/store/c/walgreen

medline.com/product/ReadyBath-

walgreens.com/store/c/cleanis-

cvs.com/shop/cvs-health-pre-mo

Hashtags:
@chronicillness
@spoonies
@mecfs
#ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #POTS @pots @fibromyalgia
#Fibromyalgia #Fibro #FMS
#chronicillness
#chroniclife
#Spoonielife
#ChronicIllnesses
#Spoonies
#Spoonie
#ChronicallyIll

Washing one’s hair if one has energy and arm limitations can be very difficult. A call participant mentioned Shampoo Caps that one places over the hair, rubs in, removes the cap and hair is cleaned – no rinsing needed. Some of these are available with fragrance free shampoo (They said they tried both of these. The Medline was what the hospital provided for their partner.) https://www.walgreens.com/store/c/walgreens-rinse-free-shampoo-cap/ID=prod6293401-product https://www.medline.com/product/ReadyBath-RinseFree-Shampoo-and-Conditioning-Caps/Z05-PF66410?question=Shampoo%20cap& They also told us there are wash gloves with similar shampoo – though they haven't tried this. https://www.walgreens.com/store/c/cleanis-aqua-pre-moistened-wash-glove,-shampoo/ID=prod6187681-product https://www.cvs.com/shop/cvs-health-pre-moistened-no-rinse-shampoo-glove-prodid-920210?skuId=920210&cgaa=QWxsb3dHb29nbGVUb0FjY2Vzc0NWU1BhZ2Vz&gStoreCode=R10694&gQT=1
flofasnix@iceshrimp.de
2025-06-14
Tom Kindlontomkindlon@disabled.social
2025-06-13

"Emergency departments aren’t trained for Long COVID [& ME/CFS] — and patients are paying the price" by @thesicktimes

thesicktimes.org/2025/06/02/em

Among other things, recommends more medical education for healthcare staff in emergency rooms & elsewhere, plus better access to telehealth

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

1/

Emergency departments aren’t trained for Long COVID — and patients are paying the price Written by Lauren May – June 2, 2025 Graphic showing a red cross with a large crack running through its center, against a backdrop with small white coronavirus particles on an orange background Miles Griffis / The Sick Times
Tom Kindlontomkindlon@disabled.social
2025-06-13

🧵
I thought this was good (as I'd expect from Oonagh & #ThereForME team):

"The importance of understanding rest: How my experience of rest as an athlete clashed with my experience of rest as a patient"

thereforme.uk/p/the-importance

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@chronicillness
@spoonies

1/

The importance of understanding rest How my experience of rest as an athlete clashed with my experience of rest as a patient Oonagh Cousins Jun 10, 2025 Today’s post is from our very own Oonagh Cousins, a member of the #ThereForME HQ team. Oonagh is a former professional athlete with the British Rowing team and was pre-selected for the Tokyo Olympics before her career was cut short by Long Covid, which she contracted in March 2020. After nearly three years of attempting to recover and return to elite sport, she made the decision to retire at the end of 2022. Since then, she has focused her efforts in the Long Covid and ME space – working at the charity Long Covid Support, as part of a social science research team at the University of Oxford, and in the #ThereForME team.

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