Title: Enhancer Remodeling by OTX2 Directs Specification and Patterning of Mammalian Definitive Endoderm
🔍 OTX2 is critical for definitive endoderm patterning.
#OTX2 #DevelopmentalBiology #Endoderm #GeneRegulation #Pub2Post https://tnyp.me/s3IJY0xx/m
🌀 How does an embryo’s genome “wake up” and begin steering development on its own?
🔗 Long-range transcription factor binding sites clustered regions may mediate transcriptional regulation through phase-separation interactions in early human embryo. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.09.017
📚 CSBJ: https://www.csbj.org/
#GeneRegulation #EmbryonicDevelopment #ChromatinBiology #Epigenetics #DevelopmentalBiology #Genomics #CellBiology
🧬 Can cells “remember” their identity without changing their DNA?
🔗 Epigenetic memory: The role of the crosstalk between histone modifications and DNA methylation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.08.034
📚 CSBJ: https://www.csbj.org/
#Epigenetics #Chromatin #GeneRegulation #DNA #MolecularBiology #SyntheticBiology #CellEngineering #Genomics #SystemsBiology #DNAmethylation
🌾 New #preprint!
"Evolutionary Rewiring of Anthocyanin Biosynthesis Pathway in Poaceae" 🎨
We show how grasses have independently restructured their anthocyanin biosynthesis pathway via:
🔹 Gene loss
🔹 Regulatory shifts
🔹 Convergent evolution
A case study in how flexible plant metabolic pathways really are.
🔗 https://doi.org/10.1101/2025.09.21.677584
#PlantScience #Evolution #Bioinformatics #GeneRegulation #Anthocyanins #Poaceae #OpenScience
@PuckerLab @samnm
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. In this #PLOSBiology Unsolved Mystery, Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.
https://plos.io/3VjfjWI
Profound study on #geneRegulation in E. coli: #transcriptionFactors generally stabilize interaction with RNA polymerase and thus reduce expression range across promoters -> better maintenance of homeostasis. https://www.science.org/doi/abs/10.1126/science.adv2064
Postdoctoral Research Fellow
UBC School of Biomedical Engineering
The SBME at UBC (Canada) is hiring two (2) full-time Postdoctoral Research Fellows in the de Boer Lab for 16 month terms.
See the full job description on jobRxiv: https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/
#biomedicalengineering #generegulation #genomics #mac...
https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/?fsp_sid=2195
Postdoctoral Research Fellow
UBC School of Biomedical Engineering
The SBME at UBC (Canada) is hiring two (2) full-time Postdoctoral Research Fellows in the de Boer Lab for 16 month terms.
See the full job description on jobRxiv: https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/
#biomedicalengineering #generegulation #genomics #mac...
https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/?fsp_sid=1859
Our next Development Presents webinar focusses on gene regulation with talks from 2025 Development PI fellows Anzy Miller and Marlies Oomen, and chaired by James Gahan.
Will you be attending?
📆 27 August, 15:00 BST (UTC+1)
Register now: https://us02web.zoom.us/webinar/register/8817538724375/WN_VSMv9w6IRbutM8WbPhBYew#/registration
#DevPres #GeneRegulation #Genes #DevelopmentalBiology #Learning #Education #Biology #Science
DNA Methylation and Hydroxymethylation: The Molecular Switches of Gene Expression
#DNA #Epigenetics #GeneRegulation #Methylation #Hydroxymethylation #TET enzymes #DNARepair #Neuroscience #BrainHealth #Genetics #Cognition #Biology #MolecularBiology #GeneticResearch #NeuralPlasticity
🔬Neue Methode zur Kartierung von Proteinbindung an DNA entwickelt💡
Ein Forschungsteam der Universität zu Köln hat DynaTag entwickelt, eine Methode, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist. Dies ist entscheidend für die Regulierung von Genen und die Entwicklung von Krankheiten wie Krebs. 🧬
Mehr dazu ▶️ https://uni.koeln/SCLU6
#uniköln #uniköln #Forschung #Research #transcription #generegulation
🔬 New: Method for mapping protein-DNA interactions developed 💡
A research team at the University of Cologne has developed DynaTag, a method that detects the binding of proteins to DNA even in a single cell. This is crucial for gene regulation and the development of diseases like cancer. 🧬
Read more ▶️ https://uni.koeln/LXJQE
#uniköln #uniköln #Forschung #Research #transcription #generegulation
Gene regulatory network analysis pointed to NFIB as a central hub. It interacts with MEIS2 and TCF4, and drives late-stage enhancer activation. Heterochronic transplants confirmed: maturation competence is sensitive to environmental timing.
#NewsMayerlab #GRN #GeneRegulation #GeneRegulatoryNetwork #Scenic+ #NFIB #Transplantation
(6/7)
🧬 Why do humans think so differently from Neanderthals? The answer might lie in gene switches, not the genes themselves.
🔗 Evolution is in the details: Regulatory differences in modern human and Neanderthal. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.052
📚 CSBJ: https://www.csbj.org/
#Genomics #Neuroscience #Evolution #HumanOrigins #NeanderthalDNA #AutismResearch #HumanEvolution #GeneRegulation #Bioinformatics #ASD #RegulatoryGenomics #TranscriptionFactors
Zinc plays a central role in the #immunesystem, & #zinc #deficient people experience increased #susceptibility to a variety of #pathogens. It is clear that zinc affects multiple aspects of the #immune system, from the barrier of the #skin to #generegulation within #lymphocytes. Zinc is crucial for normal #development & #function of cells mediating nonspecific #immunity such as #neutrophils and #naturalkillercells.
https://www.angstrom-minerals.com/?dt_id=2139817
📚 Read the full study by Antonio Ferrante & Petronia Carillo in @AnnBot (12/12)
🍃Join us to learn about the newly published paper ‘Leaf senescence-associated genes and transcriptional changes under dark conditions’ in @AnnBot by Antonio Ferrante & Petronia Carillo. 🧵(1/12)
👉 https://doi.org/pqc5
Happy to see out our latest work on studying animal body size variations using single cell transcriptomics to measure gene expression of individual cells. Learned my fair bit of statistics here, and most importantly I learned how to build wrapper functions for "complex" tasks in R (such as differntial gene expression) in a modular way. Thanks to all the authors involved! https://www.science.org/doi/10.1126/sciadv.adm7042 #singlecell #scrna #allometry #splitseq #planarians #generegulation
Genetic Differentiation and Evolutionary Transition-Transversion Bias in Vertebrates by the Example of the CYTB Gene with Emphasis on Mammals and Primates - #microevolution #macroevolution #transitiontransversionbias #mutationprocess #geneticsaturation #generegulation - https://link.springer.com/article/10.3103/S0095452724060045
🧬 This study challenges the conventional assumption that gene regulation occurs in a homogeneous nuclear environment.
🔗 From homogeneity to heterogeneity: Refining stochastic simulations of gene regulation. Computational and Structural Biotech Journal, DOI: https://doi.org/10.1016/j.csbj.2025.01.004
📚 CSBJ: https://www.csbj.org/
