Let's play "Supervillain or #antifungal lipopeptides?"
Yuan et al. will go first...
...with a new study, showing that iturin and fengycin lipopeptides inhibit #pathogenic #Fusarium in #wheat, targeting components of the #cell membrane and more!
https://doi.org/10.1111/jipb.13933
@wileyplantsci
#PlantSci #JIPB #botany
#pathogenic
I'll have a rough day today, so I start @DXMacGuffin's #ProgTuesday early with
#Pathogenic: Mass Grave Memory
https://song.link/nzxmrht7bnmbp
Pathogenic – Crowned in Corpses Review
By Tyme
Lowell, Massachusetts, is the hometown of boxer Mickey Ward, the subject of the excellent 2010 film The Fighter starring Mark Wahlberg, and it’s also the birthplace of progressive death metal quintet Pathogenic. Formed in 2004 and since relocated to The Hub,1 Pathogenic has been slugging it out in the progressive-tech, deathcore scene for nearly 20 years. With only two independently released full-lengths under their belt during this span (2011’s Cyclopean Imagery and 2019’s Pathogenic), these guys seem content to spend a lot of time training between bouts of expression. Now six years removed from their eponymous sophomore album and sporting a new, mutated logo and re-vamped lineup, Pathogenic has signed on with Skepsis Records to once again step in the ring with third album, Crowned in Corpses. Will all the roadwork and sparring pay off and see them move up a class or two, or will they remain middleweights forever?
Crowned in Corpses is by far the heaviest album that Pathogenic has recorded. Since reuniting with original vocalist Jake Burns and adding new drummer Tyler Montaquila in 2022, Pathogenic has shed much of its former progressive frivolity in exchange for brute force. With its Demanufactured riffery, the opening track, “Mass Grave Memory,” is a primary example, opting to strike Fear Factory into the hearts of men rather than broaden their Bring Me the Horizons. And while the roots of this new direction remain planted in deathcore—I don’t find anything Archspirely technical here— there’s way more death at the heart of Crowned in Corpses than there is core. Pathogenic‘s crisp, machine-gun staccato riffs, pinched squeal harmonics, melodic lead and solo work (courtesy of Justin Licht, Chris Gardino and Jake Burns) do draw Thy Art is Murder and The Red Chord comparisons but have replaced the softer jazzuflections predominant on the debut. This new sound may prove somewhat off-putting for fans of Pathogenic‘s earlier material but don’t start that ten count just yet.
Crowned in Corpses makes for a compelling listen by avoiding the more egregious deathcore tropes—primarily piggy vox and incessant beaten-like-a-dead-horse breakdowns—while maintaining flashes of past progressive atmospherics. Mid-album song “Fragments” casts the widest prog net here with its slow, bass-laden melodies, harmonic cleans and swanky solos building to a crescendo of heavy chugs and powerful raspy screams, then fading out in a haze of Stranger Things-worthy synths. With nary a hint of pretension, the song works well here, providing an oasis of respite between the body blows of the beef-heavy “Exiled from the Abyss” and the off-kilter brutality of “Crowned in Corpses.” Add in some effective acoustic work (“Dead But Not at Rest,” “The New Rot”), and Pathogenic has managed to elevate the level of brutality missing from previous releases without abandoning altogether some of the sounds that fans of the band have come to expect. Unfortunately, Pathogenic‘s new sonic direction has swallowed some of those sounds.
Dan Leahy brings a lot of talent to his bass performances, as evidenced on previous outings, but much of his work on Crowned in Corpses gets lost in the mix. Loud as one might expect, the booth work here doesn’t differ, providing little space for the instruments to breathe and, other than the aforementioned “Fragments,” muffling Leahy’s bass. Burns’ vocals, full of satisfying growls and piercing rasps, take center stage alongside the chugging guitars and Montaquila’s skin-beating drum work. Still, this is not entirely bad, as Burns’ return and Montaquila’s addition have upgraded Pathogenic‘s total package. Crowned in Corpses gets points for clocking in at just over forty-two minutes, but cutting two or more minutes from closer “Silicone Regime” would have upped the album’s overall lethality.
Like the dark king on the cover, sitting upon his throne of bones and driving steel through the skull of his final enemy, Pathogenic has made a statement with Crowned in Corpses. They have re-emerged a much leaner and meaner fighter, sporting a bag of tricks not previously displayed. I enjoyed getting to know Pathogenic, and listening to their back catalog has me rooting for Crowned in Corpses all the more for what it does and doesn’t do. Is it still deathcore? Yes. Would it be “wicked smaht” of you to give it a listen? Yes. If Pathogenic can clean up some minor issues holding them back, I could see a title shot in their future.
Rating: 3.0/5.0
DR: 7 | Format Reviewed: 320 kbps mp3
Label: Skepsis Records
Websites: pathogenic.bandcamp.com | facebook.com/pathogenicmetal
Releases Worldwide: February 7, 2025
#2025 #30 #AmericanMetal #CrownedInCorpses #DeathMetal #Deathcore #FearFactory #Feb25 #Pathogenic #ProgressiveTechnicalDeathMetal #Review #Reviews #SkepsisRecords #TheRedChord #ThyArtIsMurder
#Phylogenetic and #Pathogenic #Analysis of #H5N1 and #H5N6 High Pathogenicity Avian #Influenza Virus Isolated from #Poultry Farms (Layer and Broiler Chickens) in #Japan in the 2023/2024 Season, https://etidiohnew.blogspot.com/2024/12/phylogenetic-and-pathogenic-analysis-of.html
#BirdFlu reaches #cows in #California, the country’s largest #milk producer
The highly #pathogenic #H5N1 strain has now spread to 197 herds in 14 states.
https://arstechnica.com/science/2024/09/bird-flu-reaches-cows-in-california-the-countrys-largest-milk-producer/
Researchers at Univ Suffolk say "a reservoir of disease" is being created after discovering #bacteria naturally occur in #rivers are becoming resistant to #antibiotics due to the impact of #sewage. The university's team has isolated and analysed 500 strains of bacteria and found significant levels of #antibioticresistance.
"We're needlessly adding #pathogenic and virulence genes to bacteria found in the environment, and that could be creating a reservoir of #disease."
https://www.bbc.com/news/articles/cw4yx3wvj7yo
The #US government will pay #Moderna $176 million to develop an #mRNA #vaccine targeting #H5 and #H7 varieties of #pandemic #influenza—an award given as the highly #pathogenic #birdflu #virus #H5N1 continues to spread widely among US dairy #cattle.
The funding flows through #BARDA, the Biomedical Advanced Research and Development Authority, as part of a new Rapid Response Partnership Vehicle (#RRPV) Consortium. Phase 3 trial anticipated to begin in 2025. https://arstechnica.com/science/2024/07/us-prepares-for-bird-flu-pandemic-with-176m-moderna-vaccine-deal/
Could the blood of camel species help save us from serious diseases? | DW Documentary
What’s known as #nanobodies from the blood of #camels are at the heart of a #medical revolution. Due to their special properties, these nanobodies can be used in a variety of ways, whether in the fight against #infectious diseases, in #cancer therapy or in the diagnosis of #Alzheimer's disease.
Small #antibodies with a big impact: camel blood contains #immunological superpowers. It all began in the 1990s with a chance #discovery at the Free #University of #Brussels: students used #dromedary blood in an experiment and came across previously unknown antibodies. The university #scientists discovered that these antibodies are present in all camel species. And, they have amazing properties. Small fragments can separate from the base of the antibody -- without causing any damage and while retaining their full binding capacity.
This was the discovery of the nanobody: a tiny, extremely robust #molecule which, due to its small size, can also penetrate areas too small to be targeted by complete antibodies. The nanobody, however, can attach itself with extremely high precision to pathogenic antigens.
This discovery triggered a wave of innovations and shook up the big #pharmaceutical companies. In 2018, the first drug based on nanobodies went on the market, designed to combat an autoimmune #blood clotting disorder. Numerous potential applications were developed within a very short space of time. Whether in the fight against cancer, in Alzheimer's diagnostics or to kill #pathogenic #bacteria - the success of camel antibodies has been so resounding that many #medical research centers now have their own herds of llamas or alpacas.
But why do members of the camel family in particular have such immunological superpowers? With the help of camel experts and microbiologists, the documentary sheds light on the surprising abilities of camels and the medical revolution of nanobodies.
Concern grows as #birdflu spreads further in #US #cows: 32 herds in 8 states
Spread of highly #pathogenic avian #influenza (#H5N1) in US #dairy cows as virus continues to make way into new herds and states. Several experts say US is not sharing enough information from federal investigation into unexpected and growing #outbreak, including genetic information from isolated viruses. Spread of virus via cattle movements indicates that is cow-to-cow transmission occurring
https://arstechnica.com/science/2024/04/concern-grows-as-bird-flu-spreads-further-in-us-cows-32-herds-in-8-states/
#Cows in #Texas and #Kansas test positive for highly #pathogenic bird #flu
It is believed to be the first time the #virus, highly pathogenic #avianinfluenza (#HPAI), has been found in cows in #US., primarily affecting older cows. The virus was detected in milk from sick cows on two farms in Kansas and one in Texas. #USDA noted #farmers have found dead #birds on their properties, indicating exposure to infected birds.
The risk to public is low, and the milk supply is safe https://arstechnica.com/science/2024/03/cows-in-texas-and-kansas-test-positive-for-highly-pathogenic-bird-flu/
https://www.nature.com/articles/s44298-024-00018-4
The Wnt/β-catenin pathway is important for replication of #SARSCoV2 and other #pathogenic #RNA #viruses
New #MysteryFungi Species Spark Disease Warning
Story by Jess Thomson, February 26, 2024
Several new species of fungus have been found lurking in waterways, and they might be harmful to humans.
The new species were discovered in the sediment of riverbeds across #Spain. Many are closely related to species of #pathogenic fungi that cause infection in humans, according to a new paper in the Journal of Fungi.
The paper notes that these types of fungus that grow in the sediment of riverbeds have not been very thoroughly studied in the past. During periods of #drought they could become airborne and infect humans and animals.
"When sediments are exposed to air, these fungi may begin to produce many spores that disperse in search of a more suitable environment, and it is during this dispersion that they can interact with humans and animals," study author Josepa Gené, a researcher at the Universitat Rovira i Virgili in Spain, said in a statement.
"The infections tend to affect only the most vulnerable population and are not transmitted between humans," Gené said. "Rather, they are the result of some form of injury, among other routes of inoculation."
These fungi may also be able to infect animals and humans that swim in the rivers where they are living.
"Other fungi are opportunistic pathogens of mammals, cold-blooded animals, and other creatures, which can cause mild and serious infections, not only in animals that live in the aquatic environment but also to those that they pass through it, like us when we have a swim in a river," Gené explained.
The new species of fungus fall into the category of ascomycetes, which include #yeasts like Saccharomyces cerevisiae (used in baking and brewing), filamentous fungi like #Penicillium (which produces the antibiotic penicillin), and various plant pathogens such as the powdery #mildews and #ergot fungi.
"Among their unique characteristics, fungi feed on organic matter by decomposing it, rather than ingesting it like animals do, or absorbing nutrients through roots, as plants do," Rodney Rohde, a Regents' professor of clinical laboratory science at Texas State University, told Newsweek. "Unlike bacteria, which have simple prokaryotic cells, or cells without a true nucleus, fungi have complex eukaryotic cells, which do have a nucleus surrounded by a membrane-like animals and plants.
"In the multi-level taxonomy, or naming system, that biologists use to classify lifeforms, fungi are in their own kingdom under the domain of Eukarya. Since fungi are eukaryotic-like human cells, antibiotics are not effective and we must rely on anti-fungal medications."
The research and a further investigation could help biologists understand the potential threat posed by these fungi, and identify more like them in different environments.
"These findings allow us not only to complete our understanding of the evolution of fungi but also to determine if some of these microorganisms may be a threat to our health," Gené said. "The research has just begun but the more information we accumulate in this regard, the more able we will be to determine, for example, if there is greater potential risk in a particular area and if access to some areas needs to be controlled."
The researchers plan to investigate the fungi in the lab to see how they operate and grow at human body temperature, thus determining their pathogenic potential. This will show how likely it is that the fungus could infect people during periods of drought.
"The thing is that we have a greater understanding of them now, so we can consider establishing environmental control measures. But, before we do, there is still a lot of work to be done," Gené said.
Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes
• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2
Description of a well-preserved fossil plant-#pathogenic #fungus that infected the lycophyte Asteroxylon during the Devonian period in Scotland, around 400 million years ago. Article in Nature Communications by Christine Strullu-Derrien and others like @AlanRTSpencer - https://doi.org/10.1038/s41467-023-43276-1
How a #pathogenic #bacterium uses molecular #mimicry to compromise a #cell's #protein building factory.
https://phys.org/news/2023-12-pathogenic-bacterium-molecular-mimicry-compromise.html
#Glyphosate, pathways to modern diseases II: #Celiac #sprue and #GlutenIntolerance
2013 December
Anthony Samsel and Stephanie Seneff
"Evidence of disruption of #GutBacteria by glyphosate is available for poultry (Shehata et al., 2013), cattle (Krüger et al., 2013), and swine (Carman et al., 2013). Glyphosate disrupts the balance of gut bacteria in poultry (Shehata et al., 2013), increasing the ratio of #pathogenic #bacteria to other commensal microbes. #Salmonella and #Clostridium are highly resistant to glyphosate, whereas Enterococcus, Bifidobacteria, and Lactobacillus are especially susceptible. Glyphosate was proposed as a possible factor in the increased risk to Clostridium botulinum infection in cattle in Germany over the past ten to fifteen years (Krüger et al., 2013b). Pigs fed GMO corn and soy developed widespread intestinal #inflammation that may have been due in part to glyphosate exposure (Carman et al., 2013).
"Glyphosate Effect: #Desulfovibrio overgrowth
Dysfunction: hydrogen sulfide gas
Result: inflammation"
Full article:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/
Mycoviruses are well known for reducing the virulence in #plant #pathogenic fungi. They also affect #insect-pathogenic #fungi. Can this be a problem in #biocontrol programs against insects using such fungi? The case of #Beauveria bassiana on #corn borer larvae in China. Article in the Virology Journal by Zhengkun Zhang and others - https://doi.org/10.1186/s12985-023-02217-6
#MetagenomicsMonday🧬
#ancientDNA meets #Egyptology in groundbreaking research! 💀 Explore the untapped potential of canopic jars, bridging culture and science. 🌍 Discover the mysteries of mummies' internal organs and their #pathogenic past. 🕵️♀️🦠
#Cancer is triggered by changes in #cells that lead to the proliferation of #pathogenic #tumor cells. In order to find the most effective combination and dosage of #drugs, it is advantageous if physicians can see inside the body, so to speak, and determine what effect the drugs will have on individual cells.
#Medical #Biology #ArtificialIntelligence #sflorg
https://www.sflorg.com/2023/10/med10042301.html
Review of research on creating stable formulations of mycoparasitic #Trichoderma species for their application in the #biocontrol against #plant #pathogenic #fungi - article in Applied Microbiology and Biotechnology (2023, vol. 107, issue 18, pp. 5595-5612) by Yolanda Martinez and others - https://doi.org/10.1007/s00253-023-12687-x
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