#Neuropeptides

2025-05-09

Synaptic transmission is modulated by #neuropeptides in sensory systems & interneurons. This study shows that motor #synapses are also modulated by neuropeptidergic signaling, where lower ACh levels are compensated by upregulation of postsynaptic Ca2+ channels @PLOSBiology plos.io/4d6Ecgg

Autocrine and paracrine neuropeptidergic signaling at the Caenorhabditis elegans NMJ affects cholinergic transmission. The diagrams show the neuromuscular junction of C. elegans, with cholinergic and GABAergic motor neuron, as labeled, innervating dorsal and ventral muscle, respectively. Dyadic synapse of cholinergic neuron to GABAergic neuron and muscle. Note that the same innervation pattern exists from different sets of MNs, but with inverted topology (not represented in this graph). Also shown is the proprioceptive neuron DVA, that innervates cholinergic neurons along the ventral nerve cord (drawn more dorsal, for simplicity). Relevant ion channels and receptors are indicated on the left (NPR: neuropeptide receptor). The lefthand panel shows the situation in wild-type individuals. The righthand panel shows the situation in unc-31 (CAPS) or egl-3; aex-5 (pro-protein convertases, PCs) double mutants, where no mature neuropeptides are released or formed, thus the signaling steps induced by neuropeptides are absent.
2024-11-29

Deciphering how the mosquito brain clock drives biting patterns 🦟 πŸ•’

Javier Cavieres highlights work from Linhan Dong et al. #DuvallLab investigating a neuropeptide essential for coordinating the rhythmicity of biting & locomotor activity.

Take a look! ⬇️ πŸ‘€

prelights.biologists.com/highl

#neuroscience #biology #neuropeptides #preprint #circadian

2023-09-06

After a brief hiatus from this place, I’m elated to announce WE HAVE A NEW PUB, Y’ALL πŸ”₯🚨πŸ”₯🚨 !!!! #neuroscience #neuropeptides #neuromodulation #drosophila #connectomics #physiology 1/n nature.com/articles/s41467-023

2023-07-30

Here is my #introduction. I am a biologist interested in #neuroscience and the #evolution of cells and nervous systems. My research group studies #ciliated marine larvae from a whole-organism perspective, combining behaviour, #connectomics, #imaging, #CRISPR, #modelling and other approaches. We love marine #larvae, their #neurons, #cilia, and #neuropeptides.

Gaspar Jekelyjekely@qoto.org
2023-07-04

To get a comprehensive list of #neuropeptides, we combined #bioinformatic screening and mass spectrometry in collaboration with Amanda Kieswetter and Liesbet Temmerman at KU Leuven. We found 15 new proneuropeptides and confirmed the endogenous processing (cleavage, amidation etc) of many of them. #Nematostella has at least 33 neuropeptide precursors.
#cnidaria #neuroscience

2023-01-17

Interview with Jennifer Garrison, neuroscientist at the Buck Institute, on women's health & longevity -

youtu.be/cJZ8PQDZVWg

#aging #longevity #WomensHealth #menopause
#neuropeptides

2023-01-02

New #introduction for neuromatch.social πŸ™‚β€‹

My group investigates and defines cell types and neural circuits of the #thalamus, #hippocampus, and #cortex that contribute to spatial #memory processes.
These processes break down in #Alzheimer's disease. To understand the causes/triggers of #neurodegeneration, we study early-stage #Tau #pathology in the human #brain and in mouse models.

I previously defined various types of retinal ganglion cells using ex vivo #patchclamp recordings during my PhD in #Basel, before moving to #Oxford to work on #GABAergic #neurons of the #hippocampus, followed by the #medialseptum. My favourite technique is in vivo #extracellular recordings and #juxtacellular labelling as it enables identification of single #cells based on their firing patterns, #axon terminal distribution, and #neurochemical profile.

As an #experimentalist, my expertise is primarily in vivo #neurophysiology and #neuroanatomy. I am also interested in #consciousness, the origins of #memory, and regulation of #neuronal activity and #behaviour by #neuropeptides.

Gonzalogcordova
2022-12-30

Just Published!

Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers

link.springer.com/chapter/10.1

2022-11-19

My #introduction . I'm Nikki and I'm a #neuroscientist at Penn State University, Departments of #Biology and #BME My lab (made up of amazing trainees!) is focused on understanding how #neuropeptides regulate circuits in the brain, and how this is changed by events like stress and alcohol. I'm also an #academicmom with two kids #womeninstem #neuroscience

Gaspar Jekelyjekely@qoto.org
2022-11-09

Here is my #introduction. I am a biologist interested in #neuroscience and the #evolution of cells and nervous systems. My research group studies #ciliated marine larvae from a whole-organism perspective, combining behaviour, #connectomics, #imaging, #CRISPR, #modelling and other approaches. We love marine #larvae, their #neurons, #cilia, and #neuropeptides.

2022-11-06

Since this #twittermigration is in full swing, here's another #introduction to me. I'm a #neuroscientist and Assistant Professor in the Department of Psychiatry and Behavioral Neurobiology at the University of Alabama at Birmingham. My lab studies the #neuralcircuits and #neuropeptides mediating eating behavior using mice with the ultimate goal of informing better therapies for #diabetes, #obesity, and #eatingdisorders. I love #openscience , #DEI , #socialjustice , #3Dprinting , and #mentoring .

2022-11-05

First post, talking to the void: looking to connect with fellow neuroscientists, interested in all things #stress, #locuscoeruleus #neuropeptides #ephys Particularly invested in dialogue, open science & equity

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