Iâm excited to share that our article has been published: âBrain Topology Disruption in Early-Onset Dementia: Review of Current Findings and the Need for Network Resilience-Focused Modelsâ (http://dx.doi.org/10.1002/brb3.70903)
In this review, we highlight several important insights:
- A summary of how earlyâonset forms of dementia (including Alzheimerâs disease, frontotemporal dementia (FTD), and behavioral variant FTD) show disruption in brain network topology (both structural and functional) rather than purely focal pathology.
- Evidence that brain networks lose their optimal organisational properties (e.g., balance of segregation and integration) in earlyâonset dementia, reflecting decline in network resilience. For example, previous work has shown disrupted segregation/integration in largeâscale brain networks in Alzheimerâs/MCI.
- The concept of network resilience as a key lens: rather than only asking âwhere damage occursâ, the paper argues we should ask âhow the network topology fails to compensate, reorganise or maintain function under pathologyâ. This shifts the view to resilienceâfocused models.
- Review of methodological findings: how graphâtheoretic metrics (clustering coefficient, global/local efficiency, modularity, assortativity, smallâworldness) are being applied to neuroimaging and electrophysiology in early dementia.
- Gaps and opportunities: the need for models that integrate network resilience, longitudinal data, multimodal connectivity (structural + functional + electrophysiological) and earlyâonset cohorts; and the translational potential for biomarkers and interventions that support network integrity rather than just reduce pathology.
I believe this work contributes to bridging neuroscience, network theory, and clinical neurology, and invites discussion on how we can design interventions that strengthen brain network resilience in dementia.
Thanks to my co-authors (Hema Nawani, Sredha Sunil) and reviewers, and a huge thank you to our professor Veeky Baths for his guidance and support throughout this work.
If youâre working in cognitive neuroscience, network approaches to brain disorders, earlyâonset dementia, connectomics or translational neurology, letâs collaborate to make a real impact.
#Neuroscience #BrainNetworks #Dementia #EarlyOnsetDementia #Neurodegeneration #NetworkResilience #ClinicalNeuroscience #GraphTheory #NetworkNeuroscience #ComputationalNeuroscience