#cannabinoids

JADe (he, him)JorgeAD@mastodon.cr
2025-05-15

A farewell to Pepe Mujica, who recently passed away and really led by example ( ESPAÑOL MÁS ABAJO)

ENG: "He established an agenda of rights that marked his administration by fire; he promoted the 8-hour working day for rural workers when he was Minister of Livestock, and during his term of office, the day of the rural worker was declared, which is celebrated every 30 April; The law on the voluntary interruption of pregnancy (with the main rationale of accompanying women in their decision and not as a mere act of ending a life); the regulation of marijuana consumption, which put Uruguay in the international spotlight as a testing ground for the legalisation of all drugs in order to put an end to a war that only leaves deaths along the way."

ESP: "Consagró una agenda de derechos que marcaron a fuego su gestión; promovió las 8 horas para el trabajador rural siendo ministro de Ganadería, y durante su mandato se declaró el día del peón rural que se celebra cada 30 de abril; el matrimonio igualitario, la ley de interrupción voluntaria del embarazo (con la fundamentación principal de acompañar a las mujeres en la decisión y no como un mero acto de poner fin a una vida); la regulación del consumo de marihuana, con la que puso al Uruguay en la mira internacional como un campo de prueba hacia la legalización de todas las drogas para poner fin a una guerra que solo deja muertos por el camino."

otromundoinfo.wordpress.com/20

#pepemujica #pepe_mujica
#cannabis #cannabismedicinal #cannabislegalisierung #legaliza
#legalization #cannabinoide #thc #cbd #cbn #thca #maconha #marijuana #marihuana #PatientCare #Cannabinoids #Endocannabinoide #EfectoSéquito #entourageeffect

JADe (he, him)JorgeAD@mastodon.cr
2025-04-22

ENG: "Over 70% Of Studies Back Medical Cannabis In Cancer Treatment, Meta-Analysis Finds." They searched 10.000 published papers. Keep that in mind, next time you read the old " more reasearch is needed".

Will gladly share a proven protocol in comments if requested. Nothing for sale. Strictly educational purposes to correct such rampant intentional misinformation.

forbes.com/sites/dariosabaghi/

ESP: "Meta análisis de 10.000 estudios científicos publicados reveló una tendencia significativa ( 71.4%) que apoya el potencial terapéutico del cannabis, en particular para el manejo de los síntomas relacionados con el cáncer y efectos anticancerígenos directos."

Con gusto aclaro dudas sobre cómo usarlo para este fin. Solo pregunten en comentarios. No se vende nada, el fin es educativo para contrarrestar tanta desinformación intencional.

Enlace autotraducido:
www-forbes-com.translate.goog/

#cancer #Cannabinoids #medicine
#marijuana #cannabismedicinal
#medicalcannabis #healing #cbda #chemotherapy #cbd #quimioterapia
#thc #thca #regenerativemedicine
#herbalist #healthare #healthscience
#medical #marijuananews #cbn #homeostasis #chemo #pharmagreed
#endocannabinoidsystem #weed
#endocannabinoide #marihuana
#pharma #pharmaceuticals #healthcare #HealthCrisis #health

Edited for hashtags

JADe (he, him)JorgeAD@mastodon.cr
2025-04-18

youtube.com/shorts/mi7cS5z2cJY

ENG: Observational study on medical #cannabis use for 300 people over 50 proves medical #weed effectiveness. Patients favor high CBD low THC oral dosing ( balanced 1:1), to reduce arthritic/chronic pain and help sleep without having to chain smoke/vape. If CBD dominantes there is almost no psychotropic effect.

ESP: Ciencia moderna confirma que #marijuana medicinal alivia dolor crónico, artrítis y sueño. Estudio con 300 personas de más de 50 años revela que pacientes prefieren gotas o comestibles altos en CBD y bajos en THC. Extracto 1:1 de flor resulta aún más efectivo y evita tener que fumar/vapear para sostener efectos analgésicos/ansiolíticos. De dominar el CBD el efecto psicotropico es nulo o mínimo.

#memercredi #viernesdememes #humour #funny #humor #salud #regenerativemedicine #humornegro
#HumourNoir #science #health
#chronicillness #ChronicPainMemes
#chronicpain #thc #cbd #cbn #thca
#sleep #arthritis #cannabinoids
#cannabismedicinal #cannabismedical

ALT-TXT: Monochrome photo of old indigenous woman holding a huge joint between her swollen fingers. Text: SIGNS OF AGING: Swollen Joints

Newsrampnewsramp
2025-04-15

Groundbreaking study reveals CBD and CBG ointment potentially effective in managing eczema symptoms, tracking key skin health indicators over three-month clinical research period

Newsramp Image

Also: Does anyone know where to get #CBN gummies an oils (not CBN in small quantities, isolate not great need small quantities of other #cannabinoids & #terpenes for entourage effect). Compounding only used isolates and even more expensive than real #cannabis.

Also plain #THC #gummies or oil.

I need to mix & match depending on day and needs.

In #Australia & have permit. Can no long get it from overseas. All the suppliers I used were threatened by Australian government but meds I need are super expensive or unavailable in Australia. I’m stuck.

I tried vaping. It burned my lungs and throat and aches for a week. Also took me on extremely bad trip.I didn’t get much sleep so vaping isn’t for me. Non-smoker too. I’m trying not to wreck organs still working.

Help appreciated. Let me know if should post this elsewhere for better input. Very energy limited.

@chronicpain @chronicillness

Karl TheodorKarl_Theodor
2025-03-11

@verdantsquare ask him please 😎

and
This episode is about and cannabinoids, the compounds in . We talk to Dr. , a neurobiology professor at UC Irvine, and Dr. , a cannabis physician and researcher.

We learn how cannabinoids affect the 's , which controls many functions and .

Join us to find out the latest facts and debates in this exciting field. cannabis-med.org/de/cannabis-t

Screenshot 11.03. 2025 IACM WEBSEITE 
"Neurobiology and Cannabinoids"
This episode is about neurobiology and cannabinoids, the compounds in cannabis. We talk to Dr. Daniele Piomelli, a neurobiology professor at UC Irvine, and Dr. Franjo Grotenhermen, a cannabis physician and researcher.

We learn how cannabinoids affect the brain's endocannabinoid system, which controls many functions and health. We also discuss the pros and cons of using cannabis for various conditions, such as pain, epilepsy, PTSD, and more.

Join us to find out the latest facts and debates in this exciting field.

https://cannabis-med.org/de/cannabis-talk
JADe (he, him)JorgeAD@mastodon.cr
2025-03-07

"The #cannabis plant contains hundreds of chemical compounds. Among them #Cannabinoids , #flavonoids and #terpenes are the most relevant. Delta-nine #THC and #CBD are the most abundant cannabinoids and therefore the most studied.

However there are other minor cannabinoids such as delta-eight thc, #thca , thcv, cbg, #cbn , cbc which have been investigated to have therapeutic value (Izzo et al. 2009).

Although the compounds may have therapeutic effects taken alone (as in HEMP-derived isolate), their combined action when present together in whole plants (actually complete flower) extracts, is GREATER than the sum of their individual effects (up to 6x more potent according to recent studies). This enhanced and synergistic response is known as the #entourageeffect .

The combined action of cannabinoids and other molecules in the plant may present clinical advantages such as lower adverse effects and greater efficacy on the therapeutical management of several conditions, such as #anxiety , #depression , #pain , #inflammation , #cancer and bacterial / fungi #infectiousdiseases

If other forms of healing interest you, beyond masking symptoms with synthetic proprietary mono-molecules, check this link for a more up-to-date text on cannabis and the entourage effect:
leafwell.com/blog/entourage-ef

#healthcare #medical #healthscience #marijuananews #marijuana #weed #naturalist
#cannabismedicinal #herbalism
#solarpunk #chronicillness #regenerativemedicine #pain
#weed #autoinmunedisease #medicalcrisis #herbalmedicine

A vector illustration of a cannabis leaf with, each tip named differently: Terpenes, Flavonoids, THC, CBD and Other cannabinoids. Around it the same text as in the post. Above it the title CANNABIS AND ENTOURAGE EFFECT 1+1=3. Under it a tiny timeline: 1998: First study by the Mechoulam lab cunning an "Entourage effect describing the enhanced action of endocannabinoid 2-AG by other "silent" molecules that are similar in structure. 2011: A comparative study sponsored by GW Pharmaceuticals on the potential analgesic, antiinflammatory and anti-cancer affects of cannabinoids and cannabis extracts mediated by the TRP receptors. 2011: Doctor Ethan Russo proposes a theoretical "entourage effect" between the terpenes naturally present in cannabis that may modify the pharmacological effects of Delta-9 THC.
JADe (he, him)JorgeAD@mastodon.cr
2025-03-04

En años recientes se demostró que los cannabinoides ácidos, en flor cruda y seca de cannabis, no fumada ni cocinada, están cargados de propiedades terapéuticas.

Controlan el dolor crónico mejor que los antiiflamatorios no esteroideos (AINS como ibuprofeno, naproxeno, aspirina, etc) sin las hemorragias digestivas ni ulceras que estos a menudo provocan.

El THCa y el CBDa no son psicotrópicos pero ayudan con depresión, ansiedad, enfermedades autoinmunes, daño por contaminantes y muchas cosas más.

En este artículo enlazo estudios y explico porque su humilde flor es mejor medicina que los goteros industriales de #cáñamo #hemp y como hacer más efectivo su té herbal a partir de un estudio italiano del 2024.

jorge-alban-dobles.blogspot.co

Espero sinceramente que en estas redes libres nos cuidemos un poco más el cuerpo/mente/corazón, no solo los equipos y el software.

Veo pocos tags funcionales sobre salud en @Mastodon, como si a la gran industria farmacéutica le importara en verdad nuestra salud y no fuera parte del corporativismo que mata y destruye el mundo "for a few dollars more".

Antes de caer en la danza macabra de los especialistas médicos, prueben con el té de cannabis por un par de semanas. El autocuido también es una forma de resistencia.

#medicina #cannabinoides #autocuidado #dolor #padecimiento #autoinmune
#contaminacion #solarpunk
#solarpunkaunday #selfcare #regenerativemedicine
#medicalcannabis #weed #cannabinoids #cbd #cbda #thca

Meme basado en ilustración de tres jovencitas con vestidos de gasa blanca y lazos en la cintura. La que esta de pie sirve el té y pregunta " ¿Qué te querés? La que esta sentada a su izquierda responde " ¡Flor de mota con miel !
2025-02-28
10x color microphotograph of overripe trichomes inside a cannabis flower.

When those tiny glands start to turn brown it means oxidation is taking place and THC is turning into Cannabinol or CBN.

After years of helping my octogenarian mother deal with chronic pain from her falls and titanium protesis I realized that CBN does most of the heavy lifting THC is credited for.

To read the full story, and science behind it, follow the link to my blog. I have included the full recipe for cannabis cream, 6 years in the making.

https://jorge--alban--dobles-blogspot-com.translate.goog/2025/02/mariguanol-para-la-abuela.html?m=1&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=es&_x_tr_pto=wapp

#medicalcannabis #cannabismedicinal
#cannabinoids #weed #marijuana #pain
#paintherapy #painmanagement #dolor
#thirdage #olderpeople #solarpunk #regenerativemedicine #patients #thca #cbda #thc #cbd #terpenes #hemp #stilllife #science
#flowerpower #nature #cbn #naturephotography
10x color microphotogra of overripe trichomesinside a cannabis flower
Karl TheodorKarl_Theodor
2025-02-25

Für und und : Wirklich evidente Informationen kann man da bekommen. Das sind die absoluten Spitzenleute, was die Forschung zu anbelangt.

cannabis-med.org/de [deutsch]

cannabis-med.org/ [english]

The aim of the International Alliance for Medicines () is to advance knowledge on , , the and related topics, especially their therapeutic potential.

Screenshot 2024 The Alliance for Cannabinoid Medicines - Vorstandsmitglieder
The aim of the International Alliance for Cannabinoid Medicines (IACM) is to advance knowledge on cannabis, cannabinoids, the endocannabinoid system, and related topics especially with regard to their therapeutic potential.

The mission is achieved in particular through the following actions:

Support for research into cannabis products and the endocannabinoid system;

Promotion of exchange of information between researchers, health care practitioners, patients and the public;

Preparation and dissemination of reliable information on the pharmacology, toxicology and therapeutic potential of cannabis and modulators of the endocannabinoid system;

Monitoring and documentation of national and international developments with respect to cannabinoid therapeutics;

Co-operation with other organisations and associations sharing the mission and goals of the IACM

The IACM declares that it is the right of doctors to be able to discuss the medicinal use of cannabis with their patients.
Karl TheodorKarl_Theodor
2025-02-16

Für Anwälte und Anwältinnen und Klagende: Wirklich evidente Informationen kann man da bekommen. Das sind die absoluten Spitzenleute, was die Forschung zu anbelangt.

cannabis-med.org/de [deutsch]

cannabis-med.org/ [english]

The aim of the International Alliance for Medicines () is to advance knowledge on , , the and related topics, especially their therapeutic potential.

Screenshot 2024 The Alliance for Cannabinoid Medicines - Vorstandsmitglieder
The aim of the International Alliance for Cannabinoid Medicines (IACM) is to advance knowledge on cannabis, cannabinoids, the endocannabinoid system, and related topics especially with regard to their therapeutic potential.

The mission is achieved in particular through the following actions:

Support for research into cannabis products and the endocannabinoid system;

Promotion of exchange of information between researchers, health care practitioners, patients and the public;

Preparation and dissemination of reliable information on the pharmacology, toxicology and therapeutic potential of cannabis and modulators of the endocannabinoid system;

Monitoring and documentation of national and international developments with respect to cannabinoid therapeutics;

Co-operation with other organisations and associations sharing the mission and goals of the IACM

The IACM declares that it is the right of doctors to be able to discuss the medicinal use of cannabis with their patients.
JADe (he, him)JorgeAD@mastodon.cr
2025-01-27

@researchbuzz

Nuevo estudio de YALE afirma que los cannabinoides, CBD, CBG y CBN podría dar alivio del dolor seguro, eficaz, sin efecto psicotrópico ni la fuerte dependencia de los opioides.

news.yale.edu/2025/01/21/canna

#endomedicine #Cannabinoids #cannabinoide #cbdreceptors #painmanagement #cbn #cbg

Karl TheodorKarl_Theodor
2024-10-27

@topgras wirklich evidente Informationen kann man da bekommen. Das sind die absoluten Spitzenleute, was die Forschung zu anbelangt.

cannabis-med.org/de [deutsch]

cannabis-med.org/ [english]

The aim of the International Alliance for Medicines () is to advance knowledge on , , the and related topics, especially their therapeutic potential.

The Alliance for Cannabinoid Medicines  - Vorstandsmitglieder
The aim of the International Alliance for Cannabinoid Medicines (IACM) is to advance knowledge on cannabis, cannabinoids, the endocannabinoid system, and related topics especially with regard to their therapeutic potential.

The mission is achieved in particular through the following actions:

Support for research into cannabis products and the endocannabinoid system;

Promotion of exchange of information between researchers, health care practitioners, patients and the public;

Preparation and dissemination of reliable information on the pharmacology, toxicology and therapeutic potential of cannabis and modulators of the endocannabinoid system;

Monitoring and documentation of national and international developments with respect to cannabinoid therapeutics;

Co-operation with other organisations and associations sharing the mission and goals of the IACM

The IACM declares that it is the right of doctors to be able to discuss the medicinal use of cannabis with their patients.
Kendall Menachem SharpeKendallSharpe@mstdn.plus
2024-10-09

"A new scientific review on #cannabis and cancer concludes that a variety of cannabinoids—including #delta-9 #THC, #CBD and #cannabigerol (#CBG)—”show promising potential as anticancer agents through various mechanisms,” for example by limiting the growth and spread of tumors."

#Cannabinoids exhibit significant anticancer activities such as apoptosis induction, autophagy stimulation, cell cycle arrest, anti-proliferation, anti-angiogenesis, and metastasis inhibition.”

marijuanamoment.net/marijuana-?

2024-10-04

Cannabis has been recognized since antiquity for its sedative and hypnotic effects, and today sleep disorders are one of the commonest reasons why many people seek and recommend taking cannabinoids.

But its use raises questions: How effective are they? Can they be used long-term? Can they be combined with other treatments?

Read more about this in our article on CANNA Fundación.

fundacion-canna.es/en/morpheus

N95Bias Ⓥ🏴‍☠️currentbias@zeroes.ca
2024-09-15

Nasal sprays might help protect the upper respiratory tract, but what about the lungs? What if we had something we could vaporize and fill the lungs with that might raise the minimum infectious dose of SARSCoV2 by inhibiting cell entry?

Something that isn't psychoactive -- like CBD -- and could be used by everyone? What if regulated, plentiful, and inexpensive CBD extract could be found at every pharmacy?

"Retrospective clinical studies support antiviral activities of CBD, Δ9-THC, and cannabinoid mixtures as do some prospective clinical trials, but appropriately designed clinical trials of safety and efficacy of antiviral cannabinoids are urgently needed."

portlandpress.com/clinsci/arti

#SARSCoV2 #covid #covid19 #CBD #cannabinoids #PublicHealth #CovidIsNotOver

Xamanismo Coletivoeliasulrich@hachyderm.io
2024-04-20

"#CarlSagan, the astronomer & science communicator, speculated that #cannabis might be the 1st ever domesticated plant, the one that drove the dawn of #agriculture. The #endocannabinoid system, that regulates other systems in the human body, is where #Cannabinoids like #THC fit like a lock & a key. This is how foundational a relationship can get… you have to love that plant a whole lot to create agriculture simply to have a steady supply."
pca.st/wjj3qblb?t=20m8s

European RadiologyEurRadiology
2024-04-02

Commentary: Coagulopathy and - what the should know. (Aileen O’Shea)

Commentary 👉 rdcu.be/dCN6V
Original Article 👉 buff.ly/4auLecc

2024-02-08

#Cannabinoids as novel #AntiInflammatory drugs

by Prakash Nagarkatti, et al.
October, 2009

Abstract:

"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (#THC) as the major psychoactive principle in marijuana, as well as the identification of #cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on #immune cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate #cytokine and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress #inflammatory responses. The #endocannabinoid system is also involved in #immunoregulation. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."

Executive summary

- Cannabinoids, the active components of #CannabisSativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).

- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.

- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.

- Cannabinoids have been tested in several experimental models of autoimmune disorders such as #MultipleSclerosis, #RheumatoidArthritis, #colitis and #hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.

- Cannabinoids may also be beneficial in certain types of #cancers that are triggered by #ChronicInflammation In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.

ncbi.nlm.nih.gov/pmc/articles/

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