Secondly, the high temperature + the infection induce #AntimicrobialPeptides in the fly, which are taken up by the parasites (the host is the only food source) and which heavily disturb the #Microbiome of the wasps. This disturbance leads to the death of the wasps (~1% of the wasps emerge vs. 44-83% at low temperatures). They also simply over expressed the #AMP:s in flies, without the temperature effect and got similar results.
#AntimicrobialPeptides
Some extraordinary news for the lab just dropped, we need sometime for full disclosure
...err, we also got two papers published:
#CheesyFungi new shades of blue produced by crossing domesticated chees-making fungi @PLOS
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011669
#CoEvoSymb a kingdom wide search for #AntimicrobialPeptides transporters
https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.001380
Pipeline release! nf-core/funcscan v2.1.0 - v2.1.0 - Egyptian Koshari - 2025-03-05!
Please see the changelog: https://github.com/nf-core/funcscan/releases/tag/2.1.0
#amp #amr #antibioticresistance #antimicrobialpeptides #antimicrobialresistancegenes #arg #assembly #bgc #biosyntheticgeneclusters #contigs #function #metagenomics #naturalproducts #screening #secondarymetabolites #nfcore #openscience #nextflow #bioinformatics
Could #antimicrobial peptides get around the threat of #antibiotic resistance #AMR? This study shows that random peptide mixtures are better than trad single-sequence #AntimicrobialPeptides at avoiding evolution of resistance in #Pseudomonas #PLOSBiology https://plos.io/3L9W9NO
New on my "to-read" list: #AntimicrobialPeptides (AMPs or HDPs) are key to fight infections. But there's a building literature on their knock-on effects. This study proposes the AMP "Attacin D" is actually autotoxic, damaging #Drosophila kidneys (MTs) when induced.
Referenced link: https://phys.org/news/2023-05-biopharming-technique-yields-cost-effective-environmentally.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-05-biopharming-technique-yields-cost-effective-environmentally.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1656311395841966083#m
Biopharming technique yields cost-effective and environmentally friendly #antimicrobialpeptides @kaust_news @NatureComms https://www.nature.com/articles/s41467-023-37003-z https://phys.org/news/2023-05-biopharming-technique-yields-cost-effective-environmentally.html
Another hot-off-the-press preprint on #Drosophila host - #microbiome interactions:
Lactobacillus plantarum is resistant to host #antimicrobialpeptides (AMPs) thanks to characteristics of its peptidoglycan that make its cell wall less sensitive to AMPs than other #bacteria. 🦠
Definitely adding to my reading list! Congrats to Aranzazu et al. and Igor Iatsenko, whose new lab has been knocking it out of the park! ⚾
Referenced link: https://phys.org/news/2023-02-ai-based-finder-antimicrobial-peptides.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-02-ai-based-finder-antimicrobial-peptides.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1628776964214472710#m
Researchers develop a new AI-based 'finder' of #antimicrobialpeptides https://onlinelibrary.wiley.com/doi/10.1002/pro.4529 https://phys.org/news/2023-02-ai-based-finder-antimicrobial-peptides.html
🦠 I'm happy to present a new nf-core pipeline for people interested in functional analysis of #MicrobialGenomes / #Metagenomes / #Microbiomes !
If you're interested in mining metagenomes for functional groups such as #AntiMicrobialResistance genes, #AntiMicrobialPeptides or #BiosyntheticGeneClusters, @nf_core /funcscan automates the screening of such sequences from input contigs or genomes in a highly parallelised, portable, and reproducible manner
https://genomic.social/@nf_core@mstdn.science/109868600236675816 🧵 [1/2]
Such a pleasure to attend again the #Gordon Research Conference on #antimicrobialpeptides and catch up with the community after a 4 year break.
It is a big responsibility and at the same time a great honor to be chairing the upcoming GRC in 2025 together with Prof. Gerard Wong from #UCLA.
Looking forward to see everyone again in two years in sunny Ventura. ☀️🌊
Happy to announce this #preprint , the culmination of last 10 years. 🥳
We find that #antimicrobialpeptides are evolved to control specific #microbiome #bacteria. This example is a textbook case of host #immune #evolution being shaped by the microbiome 🦠 which depends on host #ecology.
Thanks for comments! Bit of an experiment: we are posting pre-submit to get feedback 🙂.
https://www.biorxiv.org/content/10.1101/2022.12.23.521774v2.full
#immunity #Drosophila #EvolutionaryBiology #inflammation #NFkB
"On taking a blood meal, mosquitoes with the modification produce two antimicrobial peptides (AMPs) in the gut, which impair the malaria parasite’s development. The two peptides are magainin 2, which was first found within skin secretions of the African claw frog Xenopus laevis, and melittin, a primary toxin component of the European honey bee Apis mellifera." #malaria, #antimicrobialpeptides #genedrive
Watch out the first paper of Noemie de San Nicolas! So happy to celebrate with her today!
Functional Diversification of #Oyster Big #Defensins Generates #Antimicrobial #Specificity and #Synergy against Members of the #Microbiota
https://www.biorxiv.org/content/10.1101/2022.08.24.504952v2
Our study on intrinsic effects of #antimicrobialpeptides to healthy #aging has now been reviewed by Review Commons! You can find the reviews via TRiP and our response letter (✅ in tabs on bioRxiv). Reviewers commented on a lack of sex-specific effect discussion, which I think makes for a great thread topic 🧵:
“Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should.”
#immunity #inflammation
1st post #introduction. Evolutionary Biologist by training, with interests in #MolecularEcology #ornithology #InnateImmunity #AntimicrobialPeptides and #microbiology to name a few. The #SarsCoV2 #pandemic changed the world in a lot of ways, and for me it meant a career shift to #wastewater based #epidemiology (#WBE) and #viral #evolution based at #ESR in #Aotearoa, #NewZealand #COVID #viruses #InfectiousDisease #EvolutionaryBiology
Referenced link: https://phys.org/news/2022-11-lab-pathway-antimicrobial-peptides.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-11-lab-pathway-antimicrobial-peptides.html
Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1592190383752380416#m
#Lab discovers new pathway for #antimicrobialpeptides @princeton @J_A_C_S @NatureChemistry https://www.nature.com/articles/s41557-022-01063-3 https://phys.org/news/2022-11-lab-pathway-antimicrobial-peptides.html
In the past I've worked on many other questions, including the evolution of #AntimicrobialPeptides in #frogs and the genetic basis of #SexDifferences in #strawberries.
🐸 🍓
Hi all, I work on #immunity specifically #evolution and #antimicrobialpeptides or "AMPs." I've used #Drosophila as a model, but also like to keep other species in mind about universality of principles.
Cheers! Toot toot 🐘
Google scholar: https://scholar.google.ca/citations?user=lfL-37cAAAAJ&hl=en
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